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J-GLOBAL ID：201702223238451600   Reference number：17A2006996

Suppressive effect of kamebakaurin on acetaminophen-induced hepatotoxicity by inhibiting lipid peroxidation and inflammatory response in mice

マウスにおける脂質過酸化と炎症反応を阻害することによりアセトアミノフェン誘発肝毒性に対するkamebakaurinの抑制効果【Powered by NICT】

Author (12)： Yoshioka Hiroki (College of Pharmacy, Kinjo Gakuin University, Omori, Moriyamaku, Nagoya, Aichi, Japan) ,  Aoyagi Yutaka (College of Pharmacy, Kinjo Gakuin University, Omori, Moriyamaku, Nagoya, Aichi, Japan) ,  Fukuishi Nobuyuki (College of Pharmacy, Kinjo Gakuin University, Omori, Moriyamaku, Nagoya, Aichi, Japan) ,  Gui Ming-Yu (Department of Chemistry, JiLin University, Changchun, JiLin, People’s Republic of China) ,  Jin Yong-Ri (Department of Chemistry, JiLin University, Changchun, JiLin, People’s Republic of China) ,  Li Xu-Wen (Department of Chemistry, JiLin University, Changchun, JiLin, People’s Republic of China) ,  Adachi Yoshiyuki (School of Pharmacy, Tokyo University of Pharmacy & Life Sciences, Horinouchi, Hachioji, Tokyo, Japan) ,  Ohno Naohito (School of Pharmacy, Tokyo University of Pharmacy & Life Sciences, Horinouchi, Hachioji, Tokyo, Japan) ,  Takeya Koichi (School of Pharmacy, Tokyo University of Pharmacy & Life Sciences, Horinouchi, Hachioji, Tokyo, Japan) ,  Hitotsuyanagi Yukio (School of Pharmacy, Tokyo University of Pharmacy & Life Sciences, Horinouchi, Hachioji, Tokyo, Japan) ,  Miura Nobuhiko (Division of Health Effects Research, Japan National Institute of Occupational Safety and Health, Nagao, Tamaku, Kawasaki, Kanagawa, Japan) ,  Nonogaki Tsunemasa (College of Pharmacy, Kinjo Gakuin University, Omori, Moriyamaku, Nagoya, Aichi, Japan)
Material： Pharmacological Reports  (Pharmacol Rep)
Volume： 69  Issue： 5  Page： 903-907  Publication year： 2017 
JST Material Number： A1528A  ISSN： 1734-1140  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Kamebakaurin (KA) is an ent-ka...

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Thesaurus term： alanine aminotransferase ,  aspartate aminotransferase ,  pretreatment ,  *Inflammation ,  oxidative stress ,  *Lipid Peroxidation ,  olive oil ,  intraperitoneal administration ,  *hepatic toxicity ,  inflammatory cytokine ,  active oxygen ,  plasma concentration ,  Liver damage ,  *Inflammation reaction ,  fatty acid ,  aromatic amine ,  phenolic compound ,  carboxamide ,  aminoalcohol

Author keywords (4)： Acetaminophen ,  Kamebakaurin ,  Inflammatory response ,  Oxidative stress

JST classification (2)： Diterpenes,sesterterpenes  (CF10023R) ,  Basic medicine on digestive system  (GH01020E)

Substance index (1)： Acetaminophen

Terms in the title (8)： マウス ,  脂質過酸化 ,  炎症反応 ,  阻害 ,  アセトアミノフェン ,  誘発 ,  肝毒性 ,  抑制効果