Art

J-GLOBAL ID：201702224028036698   Reference number：17A0932545

An administration of TAK-683 at a minimally effective dose for luteinizing hormone stimulation under the absence of the ovary induces luteinizing hormone surge in ovary-intact goats

卵巣がないヤギで黄体形成ホルモン生成を刺激するのに最低限必要な量のTAK-683投与による,卵巣が完全なヤギにおける黄体形成ホルモンの大量生成

Author (11)： KANAI Nahoko (Laboratory of Veterinary Reproduction, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan) ,  ENDO Natsumi (Laboratory of Veterinary Reproduction, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan) ,  OHKURA Satoshi (Laboratory of Animal Production Science, Nagoya University, Nagoya 464-8601, Japan) ,  WAKABAYASHI Yoshihiro (Laboratory of Neurobiology, National Institute of Agrobiological Sciences, Ibaraki 305-8602, Japan) ,  MATSUI Hisanori (Takeda Pharmaceutical Company Limited, Kanagawa 251-0012, Japan) ,  MATSUMOTO Hirokazu (Takeda Pharmaceutical Company Limited, Kanagawa 251-0012, Japan) ,  ISHIKAWA Kaori (Takeda Pharmaceutical Company Limited, Kanagawa 251-0012, Japan) ,  TANAKA Akira (Takeda Pharmaceutical Company Limited, Kanagawa 251-0012, Japan) ,  WATANABE Tatsuya (Takeda Pharmaceutical Company Limited, Kanagawa 251-0012, Japan) ,  OKAMURA Hiroaki (Laboratory of Neurobiology, National Institute of Agrobiological Sciences, Ibaraki 305-8602, Japan) ,  TANAKA Tomomi (Laboratory of Veterinary Reproduction, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan)
Material： Journal of Reproduction and Development  (J Reprod Dev)
Volume： 63  Issue： 3  Page： 305-310(J-STAGE)  Publication year： 2017 
JST Material Number： F0766A  ISSN： 0916-8818  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Capra hircus ,...
Semi thesaurus term： *luteinizing hormone releasing hormone ,...

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Author keywords (4)： Goats ,  Luteinizing hormone (LH) surge ,  Ovary ,  TAK-683

JST classification (2)： Reproductive physiology in general  (EJ15010E) ,  Sheep,goats  (FD02050F)

Substance index (4)： TAK-652 ,  TAK-683 ,  Progesterone ,  Dinoprost

Reference (27)：

• 1. Ohkura S, Uenoyama Y, Yamada S, Homma T, Takase K, Inoue N, Maeda K, Tsukamura H. Physiological role of metastin/kisspeptin in regulating gonadotropin-releasing hormone (GnRH) secretion in female rats. Peptides 2009; 30: 49-56.
• 2. Okamura H, Yamamura T, Wakabayashi Y. Kisspeptin as a master player in the central control of reproduction in mammals: an overview of kisspeptin research in domestic animals. Anim Sci J 2013; 84: 369-381.
• 3. Matsui H, Masaki T, Akinaga Y, Kiba A, Takatsu Y, Nakata D, Tanaka A, Ban J, Matsumoto S, Kumano S, Suzuki A, Ikeda Y, Yamaguchi M, Watanabe T, Ohtaki T, Kusaka M. Pharmacologic profiles of investigational kisspeptin/metastin analogues, TAK-448 and TAK-683, in adult male rats in comparison to the GnRH analogue leuprolide. Eur J Pharmacol 2014; 735: 77-85.
• 4. Scott G, Ahmad I, Howard K, MacLean D, Oliva C, Warrington S, Wilbraham D, Worthington P. Double-blind, randomized, placebo-controlled study of safety, tolerability, pharmacokinetics and pharmacodynamics of TAK-683, an investigational metastin analogue in healthy men. Br J Clin Pharmacol 2013; 75: 381-391.
• 5. Ohkura S, Tanaka T, Kuroiwa T, Wakbayashi Y, Ohtaki T, Kusaka M, Okamura H. Effects of investigational metastin/kisspeptin analog, TAK-683, on luteinizing hormone secretion in peripheral plasma, and gonadotropin-releasing hormone secretion in the pituitary portal circulation in goats. In ENDO Annual Meeting; 2011; Boston, USA. Abstract P2-273.

Terms in the title (6)： 卵巣 ,  ヤギ ,  黄体形成ホルモン ,  刺激 ,  量 ,  投与