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J-GLOBAL ID：201702235547023949   Reference number：17A0844139

Effects of hypnotic bromovalerylurea on microglial BV2 cells

ミクログリアBV2細胞に与える睡眠薬ブロムワレリル尿素の影響

Author (16)： Kawasaki Shun (Department of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Toon, Ehime 791-0295, Japan) ,  Kawasaki Shun (Department of Anesthesiology and Resuscitology, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan) ,  Abe Naoki (Department of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Toon, Ehime 791-0295, Japan) ,  Abe Naoki (Department of Anesthesiology and Resuscitology, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan) ,  Ohtake Fumito (Department of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Toon, Ehime 791-0295, Japan) ,  Islam Afsana (Department of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Toon, Ehime 791-0295, Japan) ,  Choudhury Mohammed Emamussalehin (Department of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Toon, Ehime 791-0295, Japan) ,  Utsunomiya Ryo (Department of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Toon, Ehime 791-0295, Japan) ,  Kikuchi Satoshi (Department of Emergency Medicine, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan) ,  Nishihara Tasuku (Department of Anesthesiology and Resuscitology, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan) ,  Kuwabara Jun (Department of Gastrointestinal Surgery and Surgical Oncology, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan) ,  Yano Hajime (Department of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Toon, Ehime 791-0295, Japan) ,  Watanabe Yuji (Department of Gastrointestinal Surgery and Surgical Oncology, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan) ,  Aibiki Mayuki (Department of Emergency Medicine, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan) ,  Yorozuya Toshihiro (Department of Anesthesiology and Resuscitology, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan) ,  Tanaka Junya (Department of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Toon, Ehime 791-0295, Japan)
Material： Journal of Pharmacological Sciences (Web)  (J Pharmacol Sci (Web))
Volume： 134  Issue： 2  Page： 116-123  Publication year： 2017 
JST Material Number： U0667A  ISSN： 1347-8613  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： cultured cell ,...
Semi thesaurus term： *cellular signal transduction ,...

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Author keywords (5)： NO ,  ATP ,  Microglia ,  Macrophage ,  Rotenone

JST classification (2)： Basic neurology  (GN01020W) ,  Basic research of antipyretic analgesics  (GW03040H)

Substance index (2)： Bromisovalum ,  Rotenone

Reference (22)：

• Kettenmann H, Kirchhoff F, Verkhratsky A. Microglia: new roles for the synaptic stripper. Neuron. 2013;77:10-18.
• Eeckhout Avd. Studien über die hypnotische Wirkung in der Vaïerian-süuregruppe. Arc Exp Path Pharmak. 1907;57:338-357.
• Kikuchi S, Nishihara T, Kawasaki S, et al. The ameliorative effects of a hypnotic bromvalerylurea in sepsis. Biochem Biophys Res Commun. 2015;459:319-326.
• Higaki H, Choudhury ME, Kawamoto C, et al. The hypnotic bromovalerylurea ameliorates 6-hydroxydopamine-induced dopaminergic neuron loss while suppressing expression of interferon regulatory factors by microglia. Neurochem Int. 2016;99:158-168.
• Ishii Y, Yamaizumi A, Kawakami A, et al. Anti-inflammatory effects of noradrenaline on LPS-treated microglial cells: suppression of NFkappaB nuclear translocation and subsequent STAT1 phosphorylation. Neurochem Int. 2015;90:56-66.

Terms in the title (4)： ミクログリア ,  細胞 ,  睡眠薬 ,  ブロムワレリル尿素