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J-GLOBAL ID：201702235602194392   Reference number：17A1958578

Procyanidins from Cinnamomi Cortex promote proteasome-independent degradation of nuclear Nrf2 through phosphorylation of insulin-like growth factor-1 receptor in A549 cells

Cinnamomi CortexからのプロシアニジンはA549細胞におけるインシュリン様成長因子-1受容体のりん酸化を介して核Nrf2のプロテアソーム非依存性分解を促進する【Powered by NICT】

Author (8)： Ohnuma Tomokazu (Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji-shi, Tokyo 192-0392, Japan) ,  Sakamoto Kazuya (Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji-shi, Tokyo 192-0392, Japan) ,  Shinoda Asumi (Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji-shi, Tokyo 192-0392, Japan) ,  Takagi Chiaki (Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji-shi, Tokyo 192-0392, Japan) ,  Ohno Shoko (Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji-shi, Tokyo 192-0392, Japan) ,  Nishiyama Takahito (Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji-shi, Tokyo 192-0392, Japan) ,  Ogura Kenichiro (Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji-shi, Tokyo 192-0392, Japan) ,  Hiratsuka Akira (Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji-shi, Tokyo 192-0392, Japan)
Material： Archives of Biochemistry and Biophysics  (ABB)
Volume： 635  Page： 66-73  Publication year： 2017 
JST Material Number： B0023A  ISSN： 0003-9861  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Many lines of evidence demonst...

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Thesaurus term： IGF1 receptor ,  proteinase inhibitor ,  human ,  transcription factor ,  drug therapy ,  tumor cell ,  *proteasome ,  *IGF1 ,  Cell Proliferation ,  *phosphorylation ,  *A549 cell ,  cysteine proteinase ,  protein expression ,  *NF-E2-Related Factor 2 ,  *procyanidin ,  *factor ,  *bioactive factor ,  *growth factor ,  *cytokine

Author keywords (6)： Nrf2 ,  Degradation ,  A549 cells ,  IGF-1R ,  Procyanidin ,  Cysteine protease

JST classification (2)： Cell physiology in general  (EF02010S) ,  Biological function  (EB03040U)

Terms in the title (11)： プロシアニジン ,  A549細胞 ,  インシュリン様成長因子-1 ,  受容体 ,  りん酸化 ,  核 ,  NRF2 ,  プロテアソーム ,  非依存性 ,  分解 ,  促進