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J-GLOBAL ID：201702237900992589   Reference number：17A0762076

Development of nonsteroidal glucocorticoid receptor modulators based on N-benzyl-N-(4-phenoxyphenyl)benzenesulfonamide scaffold

N-ベンジル-N-(4-フェノキシフェニル)ベンゼンスルホンアミド骨格に基づく非ステロイド性グルココルチコイド受容体モジュレータの開発

Author (7)： Yoshioka Hiromasa (Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, 113-0032 Tokyo, Japan) ,  Yamada Ayumi (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, 101-0062 Tokyo, Japan) ,  Nishiyama Yuko (Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, 113-0032 Tokyo, Japan) ,  Kagechika Hiroyuki (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, 101-0062 Tokyo, Japan) ,  Hashimoto Yuichi (Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, 113-0032 Tokyo, Japan) ,  Fujii Shinya (Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, 113-0032 Tokyo, Japan) ,  Fujii Shinya (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, 101-0062 Tokyo, Japan)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 25  Issue： 13  Page： 3461-3470  Publication year： Jul. 01, 2017 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *glucocorticoid receptor ,  *drug ,  immunologic disease ,  progesterone receptor ,  ligand ,  *binding site ,  chemical compound ,  toxicity test ,  concentration (ratio) ,  selectivity ,  estrogen receptor ,  NF-kappaB ,  *suppression and control ,  Structure-Activity Relationship ,  Computer Simulation ,  proton magnetic resonance ,  13C NMR ,  mass spectrometry ,  enzyme activity ,  alkaline phosphatase activity ,  Estrogen Receptor alpha ,  Estrogen Receptor beta ,  docking simulation ,  lead compound ,  *ligand binding domain ,  receptor ligand ,  *Transcription repression ,  *non-steroidal anti-inflammatory drug ,  50% inhibitory concentration ,  computer application ,  utilization ,  aromatic compound ,  sulfonamide
Semi thesaurus term： *non-steroidal anti-inflammatory agent ,  1H-NMR ,  C13NMR ,  IC50 ,  *Receptor antagonist ,  *non-steroidal anti-inflammatory agent ,  immunologic disease

JST classification (4)： Aromatic monocyclic sulfonic acids,sulfinic acids,sulfenic acids  (CF05140B) ,  Synthesis of drugs  (GV01030F) ,  Structure-activity relationship of drugs  (GV01050B) ,  Basic research of immunotherapeutic agents and blood preparations  (GW22010D)

Substance index (3)： Benzenesulfonamide ,  N-Benzyl-N-(4-phenoxyphenyl)-4-cyanobenzenesulfonamide ,  N-Benzyl-N-(4-phenoxyphenyl)-4-aminobenzenesulfonamide

Terms in the title (7)： ベンジル ,  ベンゼンスルホンアミド ,  骨格 ,  ステロイド ,  グルココルチコイド受容体 ,  モジュレータ ,  開発