Art

J-GLOBAL ID：201702238310972092   Reference number：17A0497513

Total Synthesis of the Cytotoxic Marine Triterpenoid Isodehydrothyrsiferol Reveals Partial Enantiodivergency in the Thyrsiferol Family of Natural Products

細胞毒性海産トリテルペノイドイソデヒドロチルシフェロールの全合成で明らかにされた天然産物チルシフェロール群での部分的なエナンチオ逸脱

Author (7)： Hoshino Akihiro (Department of Chemistry, Graduate School of Science, Osaka City University, Sumiyoshi-ku, Osaka, 558-8585, Japan) ,  Nakai Haruka (Department of Chemistry, Graduate School of Science, Osaka City University, Sumiyoshi-ku, Osaka, 558-8585, Japan) ,  Morino Miyako (Department of Chemistry, Graduate School of Science, Osaka City University, Sumiyoshi-ku, Osaka, 558-8585, Japan) ,  Nishikawa Keisuke (Department of Chemistry, Graduate School of Science, Osaka City University, Sumiyoshi-ku, Osaka, 558-8585, Japan) ,  Kodama Takeshi (Department of Chemistry, Graduate School of Science, Osaka City University, Sumiyoshi-ku, Osaka, 558-8585, Japan) ,  Nishikibe Kento (Department of Chemistry, Graduate School of Science, Osaka City University, Sumiyoshi-ku, Osaka, 558-8585, Japan) ,  Morimoto Yoshiki (Department of Chemistry, Graduate School of Science, Osaka City University, Sumiyoshi-ku, Osaka, 558-8585, Japan)
Material： Angewandte Chemie. International Edition  (Angewandte Chemie. International Edition in English)
Volume： 56  Issue： 11  Page： 3064-3068  Publication year： 2017 
JST Material Number： H0127B  ISSN： 1433-7851  CODEN： ACIEAY  Document type： Article
Article type： 短報  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： total synthesis ,  *triterpene ,  *Rhodophyta ,  biosynthesis ,  *absolute configuration ,  cytotoxicity ,  asymmetric synthesis ,  enantiomer
Semi thesaurus term： Laurencia viridis ,  *イソデヒドロチルシフェロール

Author keywords (5)： biosynthesis ,  configuration determination ,  cytotoxicity ,  natural products ,  total synthesis

JST classification (1)： Triterpenes  (CF10024I)

Substance index (6)： Thyrsiferol ,  Dehydrothyrsiferol ,  (2R)-2β-[(S)-1,5-Dimethyl-1-(methoxymethoxy)-4-hexenyl]-4aβ-methyl-6β-[1-(trifluoromethylsulfonyloxy)ethenyl]octahydropyrano[3,2-b]pyran ,  (2R)-2α-[2-(9-Borabicyclo[3.3.1]nonane-9-yl)ethyl]-3β-(triethylsiloxy)-3-methyl-6α-[1-(triethylsiloxy)-1-methylethyl]tetrahydro-2H-pyran ,  (2R)-2β-[(S)-1,5-Dimethyl-1-(methoxymethoxy)-4-hexenyl]-4aβ-methyl-6β-[1-methylene-3-[(2R)-3β-(triethylsiloxy)-3-methyl-6α-[1-(triethylsiloxy)-1-methylethyl]tetrahydro-2H-pyran-2α-yl]propyl]octahydropyrano[3,2-b]pyran ,  Isodehydrothyrsiferol

Terms in the title (5)： 細胞毒性 ,  全合成 ,  天然産物 ,  チルシフェロール ,  逸脱