Art

J-GLOBAL ID：201702238359420186   Reference number：17A0219617

Molecular pathogenesis of human amyloidosis: Lessons from β₂-microglobulin-related amyloidosis

ヒトアミロイド症の分子的病因:β₂-ミクログロブリン関連アミロイド症からの学習

Author (5)： Naiki Hironobu (Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui, Japan) ,  Okoshi Tadakazu (Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui, Japan) ,  Ozawa Daisaku (Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui, Japan) ,  Yamaguchi Itaru (Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui, Japan) ,  Hasegawa Kazuhiro (Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui, Japan)
Material： Pathology International  (Pathol Int)
Volume： 66  Issue： 4  Page： 193-201  Publication year： Apr. 2016 
JST Material Number： W0853A  ISSN： 1320-5463  Document type： Article
Article type： 文献レビュー  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： *Amyloidosis ,...
Semi thesaurus term： *molecular pathology ,...

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Author keywords (7)： amyloid fibril ,  amyloidosis ,  cytotoxic mechanism ,  extracellular chaperone ,  nucleation-dependent polymerization model ,  pathological molecular environment ,  thioflavin T

JST classification (3)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Biological function  (EB03040U) ,  Basic hematology  (GK01020N)

Substance index (1)： Thioflavin T

Reference (62)：

• Merlini G, Bellotti V. Molecular mechanisms of amyloidosis. N Engl J Med 2003; 349: 583-96.
• Kumar V, Abbas AK, Aster JC. Amyloidosis. In: Kumar V, Abbas AK, Aster JC, eds. Robbins basic pathology 9th ed. Philadelphia: Elsevier Saunders, 2013; 153-8.
• Sipe JD, Benson MD, Buxbaum JN, et al. Nomenclature 2014: amyloid fibril proteins and clinical classification of the amyloidosis. Amyloid 2014; 21: 221-4.
• Naiki H, Higuchi K, Hosokawa M, Takeda T. Fluorometric determination of amyloid fibrils in vitro using the fluorescent dye, thioflavin T. Anal Biochem 1989; 177: 244-9.
• Mathis CA, Mason NS, Lopresti BJ, Klunk WE. Development of positron emission tomography β-amyloid plaque imaging agents. Semin Nucl Med 2012; 42: 423-32.

Terms in the title (6)： ヒト ,  アミロイド症 ,  分子 ,  病因 ,  β2-ミクログロブリン ,  学習