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J-GLOBAL ID：201702240190710509   Reference number：17A0148711

Development of an ex vivo Brain Lactic Acid Monitoring System

脳乳酸の生体外モニタリングシステムの開発

Author (8)： Negishi Shuya (Department of Electronics and Bioinformatics, School of Science and Technology, Meiji University) ,  Kamada Shoto (Department of Electronics and Bioinformatics, School of Science and Technology, Meiji University) ,  Kajiwara Riichi (Department of Electronics and Bioinformatics, School of Science and Technology, Meiji University) ,  Kaneko Yuji (Department of Electronic & Physical Systems Major in Nano-Science & Nano-engineering, Waseda University) ,  Hyun Yoon Dong (Department of Electronic & Physical Systems Major in Nano-Science & Nano-engineering, Waseda University) ,  Sekiguchi Tetsushi (Department of Electronic & Physical Systems Major in Nano-Science & Nano-engineering, Waseda University) ,  Shoji Shuichi (Department of Electronic & Physical Systems Major in Nano-Science & Nano-engineering, Waseda University) ,  Kudo Hiroyuki (Department of Electronics and Bioinformatics, School of Science and Technology, Meiji University)
Material： 電気学会論文誌 E  (IEEJ Transactions on Sensors and Micromachines)
Volume： 137  Issue： 1  Page： 38-43(J-STAGE)  Publication year： 2017 
JST Material Number： L3098A  ISSN： 1341-8939  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *brain diagnosis ,...
Semi thesaurus term： in vitro test ,...

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Author keywords (6)： Flow injection ,  lactic acid ,  brain ,  ex vivo biomonitoring ,  electrochemical ,  real-time

JST classification (3)： Analytical instruments  (CC02020S) ,  Bioassay  (EA03060N) ,  Neurologic diagnosis  (GN02000H)

Substance index (2)： Lactic acid ,  Glucose

Reference (26)：

• (1) M. T. Wyss, R. Jolivet, A. Buck, P. J. Magistretti, and B. Weber : “In vivo evidence for lactate as a neuronal energy source”, J Neurosci, Vol. 31, pp. 7477-85 (2011)
• (2) J. J. Rodriguez-Arellano, V. Parpura, R. Zorec, and A. Verkhratsky : “Astrocytes in physiological aging and Alzheimer’s disease”, Neuroscience, Vol. 323, pp. 170-82 (2016)
• (3) R. A. Swanson : “Physiologic coupling of glial glycogen metabolism to neuronal activity in brain”, Canadian Journal of Physiology and Pharmacology, Vol. 70, pp. S138-S144 (1992)
• (4) A. Suzuki, S. A. Stern, O. Bozdagi, G. W. Huntley, R. H. Walker, P. J. Magistretti, et al.: “Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation”, Cell, Vol. 144, pp. 810-823 (2011)
• (5) J. M. Ross, J. Oberg, S. Brene, G. Coppotelli, M. Terzioglu, K. Pernold, et al.: “High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio”, Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, pp. 20087-20092 (2010)

Terms in the title (4)： 脳 ,  乳酸 ,  モニタリングシステム ,  開発