Art

J-GLOBAL ID：201702241367073863   Reference number：17A0211312

Triterpenes suppress octanoylated ghrelin production in ghrelin-expressing human gastric carcinoma cells

トリテルペンはグレリン発現ヒト胃癌細胞のオクタノイル化グレリン産生を抑制する

Author (6)： NAKAJIMA Kensuke (Graduate School of Pharmaceutical Sciences, Nagasaki University) ,  OISO Shigeru (Graduate School of Pharmaceutical Sciences, Nagasaki University) ,  UTO Takuhiro (Graduate School of Pharmaceutical Sciences, Nagasaki University) ,  MORINAGA Osamu (Department of Natural Medicines, Daiichi University of Pharmacy) ,  SYOYAMA Yukihiro (Graduate School of Pharmaceutical Sciences, Nagasaki University) ,  KARIYAZONO Hiroko (Graduate School of Pharmaceutical Sciences, Nagasaki University)
Material： Biomedical Research  (Biomed Res)
Volume： 37  Issue： 6  Page： 343-349(J-STAGE)  Publication year： 2016 
JST Material Number： Z0236B  ISSN： 0388-6107  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *pentacyclic triterpene ,...
Semi thesaurus term： オクタノイル化 ,...

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JST classification (2)： Basic research of drugs acting on digestive system  (GW09010Q) ,  Other hormones of verterbrates  (EB08070K)

Substance index (8)： Asiatic acid ,  Betulic acid ,  2α-Hydroxyursolic acid ,  Glycyrrhetinic Acid ,  Oleanolic acid ,  Ursolic acid ,  β-Amyrin ,  Uvaol

Reference (27)：

• 1 Al Massadi O, Tschöp MH and Tong J (2011) Ghrelin acylation and metabolic control. Peptides 32, 2301-2308.
• 2 Banno N, Akihisa T, Tokuda H, Yasukawa K, Higashihara H, Ukiya M, Watanabe K, Kimura Y, Hasegawa J and Nishino H (2004) Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects. Biosci Biotechnol Biochem 68, 85-90.
• 3 Chen H, Yang J, Zhang Q, Chen LH and Wang Q (2012) Corosolic acid ameliorates atherosclerosis in apolipoprotein E-deficient mice by regulating the nuclear factor-κB signaling pathway and inhibiting monocyte chemoattractant protein-1 expression. Circ J 76, 995-1003.
• 4 de Melo CL, Queiroz MG, Arruda Filho AC, Rodrigues AM, de Sousa DF, Almeida JG, Pessoa OD, Silveira ER, Menezes DB, Melo TS, Santos FA and Rao VS (2009) Betulinic acid, a natural pentacyclic triterpenoid, prevents abdominal fat accumulation in mice fed a high-fat diet. J Agric Food Chem 57, 8776-8781.
• 5 de Melo CL, Queiroz MG, Fonseca SG, Bizerra AM, Lemos TL, Melo TS, Santos FA and Rao VS (2010) Oleanolic acid, a natural triterpenoid improves blood glucose tolerance in normal mice and ameliorates visceral obesity in mice fed a high-fat diet. Chem Biol Interact 185, 59-65.

Terms in the title (5)： トリテルペン ,  グレリン ,  発現 ,  ヒト ,  胃癌細胞