Art
J-GLOBAL ID：201702241503593597   Reference number：17A1426889

Pyruvate kinase M1 interacts with A-Raf and inhibits endoplasmic reticulum stress-induced apoptosis by activating MEK1/ERK pathway in mouse insulinoma cells

ピルビン酸キナーゼM1はA-Rafと相互作用し,マウスインシュリノーマ細胞におけるMEK1/ERK経路を活性化することにより小胞体ストレス誘導アポトーシスを阻害する【Powered by NICT】
Author (5)：
Horiuchi Yuta

About Horiuchi Yuta

(Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan)

About Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan

, 
Nakatsu Daiki

About Nakatsu Daiki

(Cell Biology Unit, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsutacho, Midori-ku, Yokohama, Kanagawa 226-8503, Japan)

About Cell Biology Unit, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsutacho, Midori-ku, Yokohama, Kanagawa 226-8503, Japan

, 
Kano Fumi

About Kano Fumi

(Cell Biology Unit, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsutacho, Midori-ku, Yokohama, Kanagawa 226-8503, Japan)

About Cell Biology Unit, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsutacho, Midori-ku, Yokohama, Kanagawa 226-8503, Japan

, 
Murata Masayuki

About Murata Masayuki

(Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan)

About Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan

, 
Murata Masayuki

About Murata Masayuki

(Cell Biology Unit, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsutacho, Midori-ku, Yokohama, Kanagawa 226-8503, Japan)

About Cell Biology Unit, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsutacho, Midori-ku, Yokohama, Kanagawa 226-8503, Japan


Material：
Cellular Signalling  (Cell Signal)

About Cellular Signalling


Volume： 38  Page： 212-222  Publication year： 2017 
JST Material Number： T0667A  ISSN： 0898-6568  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)
Abstract/Point：
Abstract/Point
Japanese summary of the article(about several hundred characters).
All summary is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
Apoptotic death of pancreatic ...
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Thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
*interaction

About interaction

, 
caspase

About caspase

, 
type 2 diabetes mellitus

About type 2 diabetes mellitus

, 
*pyruvate kinase

About pyruvate kinase

, 
*ER stress

About ER stress

, 
*endoplasmic reticulum

About endoplasmic reticulum

, 
*apoptosis

About apoptosis

, 
phosphorylation

About phosphorylation


Semi thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
カスパーゼ3

About カスパーゼ3

, 
カスパーゼ9

About カスパーゼ9

, 
遺伝子ノックダウン法

About 遺伝子ノックダウン法

, 
PKM2

About PKM2

, 
アイソフォーム

About アイソフォーム

, 
*MEK1

About MEK1

, 
*rafキナーゼ

About rafキナーゼ

, 【Automatic Indexing@JST】
Author keywords (6)：
Apoptosis

About Apoptosis

, 
Pancreatic β cell

About Pancreatic β cell

, 
Diabetes

About Diabetes

, 
PKM1

About PKM1

, 
A-Raf

About A-Raf

, 
ER stress

About ER stress

JST classification (1)：
JST classification
Category name(code) classified by JST.
Cell physiology in general 
(EF02010S)

About Cell physiology in general

Terms in the title (14)：
Terms in the title
Keywords automatically extracted from the title.
ピルビン酸キナーゼ

About ピルビン酸キナーゼ

, 
Raf

About Raf

, 
相互作用

About 相互作用

, 
マウス

About マウス

, 
インシュリノーマ

About インシュリノーマ

, 
細胞

About 細胞

, 
MEK1

About MEK1

, 
ERK

About ERK

, 
経路

About 経路

, 
活性化

About 活性化

, 
小胞体ストレス

About 小胞体ストレス

, 
誘導

About 誘導

, 
アポトーシス

About アポトーシス

, 
阻害

About 阻害


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