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J-GLOBAL ID：201702242086676501   Reference number：17A1233331

Development of HGF-binding aptamers with the combination of G4 promoter-derived aptamer selection and in silico maturation

G4プロモーターderivedアプタマー選択とin silico成熟を併用したHGF結合アプタマーの開発【Powered by NICT】

Author (8)： Yokoyama Tomomi (Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan) ,  Tsukakoshi Kaori (Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan) ,  Yoshida Wataru (School of Biotechnology and Bioscience, Tokyo University of Technology, Hachioji, Tokyo, Japan) ,  Saito Taiki (Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan) ,  Teramoto Kentaro (Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan) ,  Savory Nasa (Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan) ,  Abe Koichi (Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan) ,  Ikebukuro Kazunori (Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan)
Material： Biotechnology and Bioengineering  (Biotechnol Bioeng)
Volume： 114  Issue： 10  Page： 2196-2203  Publication year： 2017 
JST Material Number： D0019A  ISSN： 0006-3592  CODEN： BIBIAU  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： We describe the selection of a...

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Thesaurus term： polymerase chain reaction ,  *promoter (genetics) ,  HGF ,  screening (inspection) ,  heavy chain ,  centralization ,  directed evolution ,  bioinformatics ,  Ligands ,  SELEX Aptamer Technique ,  *in silico ,  *aptamer
Semi thesaurus term： 特異性 , 【Automatic Indexing@JST】

Author keywords (5)： aptamer selection ,  aptamer improvement ,  G-quadruplex ,  in silico ,  hepatocyte growth factor

JST classification (2)： Nucleic acids in general  (EB04010U) ,  Molecular and genetic information processing  (JE15040B)

Terms in the title (6)： プロモーター ,  アプタマー ,  成熟 ,  併用 ,  HGF ,  開発