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J-GLOBAL ID：201702245309324232   Reference number：17A1135991

Transient Global Cerebral Ischemia Induces RNF213, a Moyamoya Disease Susceptibility Gene, in Vulnerable Neurons of the Rat Hippocampus CA1 Subregion and Ischemic Cortex

ラット海馬CA1亜領域の脆弱なニューロンと虚血性皮質における一過性全脳虚血はモヤモヤ病感受性遺伝子であるRNF213を誘導する

Author (8)： Sato-Maeda Mika (Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan) ,  Fujimura Miki (Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan) ,  Rashad Sherif (Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan) ,  Morita-Fujimura Yuiko (Frontier Research Institute for Interdisciplinary Sciences (FRIS), Tohoku University, Sendai, Japan) ,  Niizuma Kuniyasu (Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan) ,  Sakata Hiroyuki (Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan) ,  Ikawa Shuntaro (Department of Project Programs, Institute of Development, Aging and Cancer (IDAC), Tohoku University, Sendai, Japan) ,  Tominaga Teiji (Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan)
Material： Journal of Stroke & Cerebrovascular Diseases  (J Stroke Cerebrovasc Dis)
Volume： 26  Issue： 9  Page： 1904-1911  Publication year： Sep. 2017 
JST Material Number： W1420A  ISSN： 1052-3057  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： Rattus ,...
Semi thesaurus term： CA1 Region, Hippocampal ,...

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Author keywords (4)： Moyamoya disease ,  RNF213 gene ,  in situ RNA hybridization ,  transient global cerebral ischemia (tGCI)

JST classification (1)： Basic medicine on cardiovascular system  (GJ01020K)

Reference (20)：

• Joazeiro, C.A., Weissman, A.M. RING finger proteins: mediators of ubiquitin ligase activity. Cell. 2000;102:549-552.
• Banh, R.S., Iorio, C., Marcotte, R. et al. PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia. Nat Cell Biol. 2016;18:803-813.
• Fujimura, M., Tominaga, T. Current status of revascularization surgery for moyamoya disease: special consideration for its physiological reorganization system “internal carotid-external carotid (IC-EC) conversion”. Tohoku J Exp Med. 2015;236:45-53.
• Kamada, F., Aoki, Y., Narisawa, A. et al. A genome-wide association study identifies RNF213 as the first Moyamoya disease gene. J Hum Genet. 2011;56:34-40.
• Liu, W., Morito, D., Takashima, S. et al. Identification of RNF213 as a susceptibility gene for moyamoya disease and its possible role in vascular development. PLoS ONE. 2011;6 : e22542.

Terms in the title (9)： ラット ,  海馬 ,  ニューロン ,  虚血 ,  皮質 ,  全脳虚血 ,  モヤモヤ病 ,  感受性遺伝子 ,  誘導