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J-GLOBAL ID：201702246011326801   Reference number：17A0016909

Atranorin and lecanoric acid antagonize TCDD-induced xenobiotic response element-driven activity, but not xenobiotic response element-independent activity

Atranorinとlecanoric acidはTCDD誘発生体異物応答要素駆動型活性に拮抗するが,生体異物応答要素非依存性活性には拮抗しない

Author (5)： Nakashima Ken-ichi (Laboratory of Medicinal Resources, School of Pharmacy, Aichi Gakuin University, Nagoya, Aichi, Japan) ,  Tanabe Hiroki (Laboratory of Medicinal Resources, School of Pharmacy, Aichi Gakuin University, Nagoya, Aichi, Japan) ,  Fujii-Kuriyama Yoshiaki (Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan) ,  Hayashi Hidetoshi (Department of Cell Signaling, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Aichi, Japan) ,  Inoue Makoto (Laboratory of Medicinal Resources, School of Pharmacy, Aichi Gakuin University, Nagoya, Aichi, Japan)
Material： Journal of Natural Medicines  (J Nat Med)
Volume： 70  Issue： 3  Page： 476-482  Publication year： 2016 
JST Material Number： L5856A  ISSN： 1340-3443  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： Ah receptor ,...
Semi thesaurus term： Cyanophyta ,...

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Author keywords (5)： Aryl hydrocarbon receptor ,  Lichen substances ,  Atranorin ,  Lecanoric acid ,  Selective AhR modulators

JST classification (1)： Microorganism biochemistry  (EG03020N)

Substance index (5)： 2,3,7,8-TCDD ,  Atranorin ,  Lecanoric acid ,  Squamatic acid ,  Gyrophoric acid

Reference (24)：

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• Cox MB, Miller CA III (2004) Cooperation of heat shock protein 90 and p23 in aryl hydrocarbon receptor signaling. Cell Stress Chaperones 9:4-20
• Ma Q, Whitlock JP Jr (1997) A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Biol Chem 272:8878-8884
• Shimada T, Inoue K, Suzuki Y, Kawai T, Azuma E, Nakajima T, Shindo M, Kurose K, Sugie A, Yamagishi Y, Fujii-Kuriyama Y, Hashimoto M (2002) Arylhydrocarbon receptor-dependent induction of liver and lung cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in genetically engineered C57BL/6 J mice. Carcinogenesis 23:1199-1207

Terms in the title (7)： TCDD ,  誘発 ,  生体異物 ,  応答要素 ,  活性 ,  拮抗 ,  非依存性