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J-GLOBAL ID：201702247003305151   Reference number：17A0041033

M3 Muscarinic Receptor Signaling Stabilizes a Novel Mutant Human Ether-a-Go-Go-Related Gene Channel Protein via Phosphorylation of Heat Shock Factor 1 in Transfected Cells

M3ムスカリン受容体シグナル伝達はトランスフェクション細胞において熱ショック因子1のりん酸化を介して新規変異ヒトEther-a-Go-Go関連遺伝子チャンネル蛋白質を安定化させる

Author (20)： Mahati Endang (Division of Regenerative Medicine and Therapeutics, Department of Genetic Medicine and Regenerative Therapeutics, Institute of Regenerative Medicine and Biofunction, Tottori University Graduate School of Medical Science) ,  Mahati Endang (Department of Pharmacology and Therapeutics, Faculty of Medicine, Diponegoro University) ,  Li Peili (Division of Regenerative Medicine and Therapeutics, Department of Genetic Medicine and Regenerative Therapeutics, Institute of Regenerative Medicine and Biofunction, Tottori University Graduate School of Medical Science) ,  Kurata Yasutaka (Department of Physiology, Kanazawa Medical University) ,  Maharani Nani (Division of Regenerative Medicine and Therapeutics, Department of Genetic Medicine and Regenerative Therapeutics, Institute of Regenerative Medicine and Biofunction, Tottori University Graduate School of Medical Science) ,  Maharani Nani (Department of Pharmacology and Therapeutics, Faculty of Medicine, Diponegoro University) ,  Maharani Nani (Center for Biomedical Research (CEBIOR), Faculty of Medicine, Diponegoro University) ,  Ikeda Nobuhito (Division of Regenerative Medicine and Therapeutics, Department of Genetic Medicine and Regenerative Therapeutics, Institute of Regenerative Medicine and Biofunction, Tottori University Graduate School of Medical Science) ,  Sakata Shinji (Department of Pediatrics, Faculty of Medicine, Tottori University) ,  Ogura Kazuyoshi (Division of Cardiovascular Medicine, Department of Molecular Medicine and Therapeutics, Faculty of Medicine, Tottori University) ,  Miake Junichiro (Division of Cardiovascular Medicine, Department of Molecular Medicine and Therapeutics, Faculty of Medicine, Tottori University) ,  Aiba Takeshi (Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center) ,  Shimizu Wataru (Division of Cardiology and Regenerative Medicine, Nippon Medical School) ,  Nakasone Naoe (Department of Biological Regulation, Faculty of Medicine, Tottori University) ,  Ninomiya Haruaki (Department of Biological Regulation, Faculty of Medicine, Tottori University) ,  Higaki Katsumi (Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University) ,  Yamamoto Kazuhiro (Division of Cardiovascular Medicine, Department of Molecular Medicine and Therapeutics, Faculty of Medicine, Tottori University) ,  Nakai Akira (Department of Biochemistry and Molecular Biology, Yamaguchi University School of Medicine) ,  Shirayoshi Yasuaki (Division of Regenerative Medicine and Therapeutics, Department of Genetic Medicine and Regenerative Therapeutics, Institute of Regenerative Medicine and Biofunction, Tottori University Graduate School of Medical Science) ,  Hisatome Ichiro (Division of Regenerative Medicine and Therapeutics, Department of Genetic Medicine and Regenerative Therapeutics, Institute of Regenerative Medicine and Biofunction, Tottori University Graduate School of Medical Science)
Material： Circulation Journal  (Circ J)
Volume： 80  Issue： 12  Page： 2443-2452(J-STAGE)  Publication year： 2016 
JST Material Number： F0908A  ISSN： 1346-9843  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *M3 receptor ,...
Semi thesaurus term： cellular signal transduction ,...

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Author keywords (5)： Carbachol ,  Heat shock factor 1 (HSF1) ,  Human ether-a-go-go-related gene (hERG) ,  Long QT syndrome type 2 (LQT2) ,  M3-mACh

JST classification (2)： Basic medicine on cardiovascular system  (GJ01020K) ,  Basic research of parasympathetics  (GW05032S)

Substance index (1)： Carbachol

Reference (27)：

• 1. Sanguinetti MC, Jiang C, Curran ME, Keating MT. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the I_Kr potassium channel. Cell 1995; 81: 299-307.
• 2. Wilde A, Tan HL. Inherited arrhythmia syndromes. Circ J 2007; 71: 12-19.
• 3. Nishizaki M, Hiraoka M. Gene mutations associated with atrioventricular block complicated by long QT syndrome. Circ J 2010; 74: 2546-2547.
• 4. Anderson CL, Delisle BP, Anson BD, Kilby JA, Will ML, Tester DJ, et al. Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism. Circulation 2006; 113: 365-373.
• 5. Sorger PK. Heat shock factor and the heat shock response. Cell 1991; 65: 363-366.

Terms in the title (12)： ムスカリン受容体 ,  シグナル伝達 ,  トランスフェクション ,  細胞 ,  熱ショック因子1 ,  りん酸化 ,  変異 ,  ヒト ,  遺伝子 ,  チャンネル ,  蛋白質 ,  安定化