Art
J-GLOBAL ID:201702247616021413
Reference number:17A0561355
Arabilin overcomes resistance to AR-targeted therapy
アラビリンはAR-標的治療への抵抗を克服する
Author (3):
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Material:
Volume:
70
Issue:
3
Page:
328-330 (WEB ONLY)
Publication year:
Mar. 2017
JST Material Number:
U0320A
ISSN:
0021-8820
Document type:
Article
Article type:
原著論文
Country of issue:
Germany, Federal Republic of (DEU)
Language:
ENGLISH (EN)
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Basic research of antitumor(=antineoplastic)antibiotics
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Reference (14):
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Heinlein, C. A. & Chang, C. Androgen receptor in prostate cancer. Endocr. Rev. 25, 276-308 (2004).
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Chen,C.D. et al. Molecular determinants of resistance to antiandrogen therapy. Nat. Med. 10, 33-39 (2004).
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Tran, C. et al. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science 324, 787-790 (2009).
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Kawamura, T. et al. Isolation and structure elucidation of a novel androgen antagonist, arabilin, produced by Streptomyces sp. MK756-CF1. J. Antibiot. 63, 601-605 (2010).
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Lim, H. N. & Parker, K. A. Total synthesis of the potent androgen receptor antagonist (-)-arabilin: a strategic, biomimetic [1,7]-hydrogen shift. J. Am. Chem. Soc. 133, 20149-20151 (2011).
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