Art

J-GLOBAL ID：201702250300951770   Reference number：17A1371026

Effects of Ascorbyl-2-phosphate Magnesium on Human Keratinocyte Toxicity and Pathological Changes by Sorafenib

ソラフェニブによるヒトケラチン細胞毒性と病理的変化に対するアスコルビル-2-リン酸マグネシウムの作用

Author (16)： Yamamoto Kazuhiro (Department of Pharmacy, Kobe University Hospital) ,  Shichiri Hiroaki (Division of Pharmaceutics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine) ,  Ishida Takahiro (R&D Department, Momotani Juntenkan Ltd.) ,  Kaku Kenta (Division of Pharmaceutics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine) ,  Nishioka Tatsuya (Department of Pharmacy, Kobe University Hospital) ,  Kume Manabu (Department of Pharmacy, Kobe University Hospital) ,  Makimoto Hiroo (Department of Pharmacy, Kobe University Hospital) ,  Nakagawa Tsutomu (Department of Pharmacy, Kobe University Hospital) ,  Nakagawa Tsutomu (Division of Pharmaceutics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine) ,  Hirano Takeshi (Division of Pharmaceutics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine) ,  Hirano Takeshi (Graduate School of Pharmaceutical Sciences, Health Sciences University of Hokkaido) ,  Bito Toshinori (Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine) ,  Nishigori Chikako (Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine) ,  Yano Ikuko (Department of Pharmacy, Kobe University Hospital) ,  Yano Ikuko (Division of Pharmaceutics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine) ,  Hirai Midori (Division of Pharmaceutics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 40  Issue： 9  Page： 1530-1536(J-STAGE)  Publication year： 2017 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： keratinocyte ,...
Semi thesaurus term： STAT3 ,...

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Author keywords (8)： vitamin C ,  multi-targeted tyrosine kinase inhibitor ,  hand-foot skin reaction (HFSR) ,  ascorbic acid ,  vitamin C ,  multi-targeted tyrosine kinase inhibitor ,  hand-foot skin reaction (HFSR) ,  ascorbic acid

JST classification (2)： Basic dermatology  (GF01020Y) ,  Basic research of drugs acting on integumentum commune  (GW12010Y)

Substance index (2)： L-Ascorbic acid 2-phosphoric acid magnesium salt ,  Sorafenib

Reference (29)：

• 1) Lee WJ, Lee JL, Chang SE, Lee MW, Kang YK, Choi JH, Moon KC, Koh JK. Cutaneous adverse effects in patients treated with the multitargeted kinase inhibitors sorafenib and sunitinib. Br. J. Dermatol., 161, 1045-1051 (2009).
• 2) Nardone B, Hensley JR, Kulik L, West DP, Mulcahy M, Rademaker A, Lacouture ME. The effect of hand-foot skin reaction associated with the multikinase inhibitors sorafenib and sunitinib on health-related quality of life. J. Drugs Dermatol., 11, e61-e65 (2012).
• 3) Poprach A, Pavlik T, Melichar B, Puzanov I, Dusek L, Bortlicek Z, Vyzula R, Abrahamova J, Buchler T. Skin toxicity and efficacy of sunitinib and sorafenib in metastatic renal cell carcinoma: a national registry-based study. Ann. Oncol., 23, 3137-3143 (2012).
• 4) Yamamoto K, Mizumoto A, Nishimura K, Uda A, Mukai A, Yamashita K, Kume M, Makimoto H, Bito T, Nishigori C, Nakagawa T, Hirano T, Hirai M. Association of toxicity of sorafenib and sunitinib for human keratinocytes with inhibition of signal transduction and activator of transcription 3 (STAT3). PLOS ONE, 9, e102110 (2014).
• 5) Yamamoto K, Shinomiya K, Ioroi T, Hirata S, Harada K, Suno M, Nishioka T, Kume M, Makimoto H, Nakagawa T, Hirano T, Bito T, Nishigori C, Miyake H, Fujisawa M, Hirai M. Association of single nucleotide polymorphisms in STAT3 with hand-foot skin reactions in patients with metastatic renal cell carcinoma treated with multiple tyrosine kinase inhibitors: A retrospective analysis in Japanese patients. Target. Oncol., 11, 93-99 (2016).

Terms in the title (4)： ソラフェニブ ,  細胞毒性 ,  病理 ,  リン酸マグネシウム