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J-GLOBAL ID：201702252400384951   Reference number：17A1379549

Cardiac overexpression of Epac1 in transgenic mice rescues lipopolysaccharide-induced cardiac dysfunction and inhibits Jak-STAT pathway

トランスジェニックマウスにおけるEpac1の心臓過剰発現はリポ多糖類誘発心機能不全を救済し,Jak-STAT経路を阻害する【Powered by NICT】

Author (25)： Jin Huiling (Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan) ,  Fujita Takayuki (Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan) ,  Jin Meihua (Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan) ,  Jin Meihua (Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Osaka 565-8565, Japan) ,  Kurotani Reiko (Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan) ,  Kurotani Reiko (Department of Physiology, Biochemical Engineering, Faculty of Engineering, Yamagata University, Yamagata 992-8510, Japan) ,  Namekata Iyuki (Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Chiba 274-8510, Japan) ,  Hamaguchi Shogo (Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Chiba 274-8510, Japan) ,  Hidaka Yuko (Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan) ,  Cai Wenqian (Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan) ,  Suita Kenji (Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan) ,  Suita Kenji (Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama 230-8501, Japan) ,  Ohnuki Yoshiki (Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama 230-8501, Japan) ,  Mototani Yasumasa (Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama 230-8501, Japan) ,  Shiozawa Kouichi (Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama 230-8501, Japan) ,  Prajapati Rajesh (Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan) ,  Liang Chen (Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan) ,  Umemura Masanari (Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan) ,  Yokoyama Utako (Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan) ,  Sato Motohiko (Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan) ,  Sato Motohiko (Department of Physiology, Aichi Medical University, Aichi 480-1195, Japan) ,  Tanaka Hikaru (Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, Chiba 274-8510, Japan) ,  Okumura Satoshi (Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan) ,  Okumura Satoshi (Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama 230-8501, Japan) ,  Ishikawa Yoshihiro (Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan)
Material： Journal of Molecular and Cellular Cardiology  (J Mol Cell Cardiol)
Volume： 108  Page： 170-180  Publication year： 2017 
JST Material Number： E0538A  ISSN： 0022-2828  CODEN： JMCDAY  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Pro-inflammatory cytokines are...

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Thesaurus term： cardiac insufficiency ,  inflammatory cytokine ,  *lipopolysaccharide ,  phosphorylation ,  *transgenic mouse ,  dysfunction ,  *heart ,  cardiac myocyte ,  protein kinase A ,  *STAT transcription factor ,  catecholamine ,  adenine nucleotide ,  ribonucleotide ,  cyclic nucleotide
Semi thesaurus term： *Epac蛋白質 ,  *心機能 ,  *過剰発現 , 【Automatic Indexing@JST】

Author keywords (5)： Heart failure ,  cAMP ,  Epac ,  Cytokine ,  Signal transduction

JST classification (2)： Biological function  (EB03040U) ,  Transport of cell membrane  (EF04020R)

Substance index (1)： cAMP

Terms in the title (10)： トランスジェニックマウス ,  心臓 ,  過剰発現 ,  リポ多糖類 ,  誘発 ,  心機能不全 ,  JAK ,  Stat ,  経路 ,  阻害