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J-GLOBAL ID：201702256611122198   Reference number：17A1904715

Carbonic Anhydrase Inhibitors Induce Developmental Toxicity During Zebrafish Embryogenesis, Especially in the Inner Ear

炭酸アンヒドラーゼ阻害剤は特に内耳におけるゼブラフィッシュ胚発生時に発生毒性を誘導する

Author (7)： MATSUMOTO Hiroko (Tokyo Univ. Pharmacy and Life Sci., Tokyo, JPN) ,  FUJIWARA Shoko (Tokyo Univ. Pharmacy and Life Sci., Tokyo, JPN) ,  MIYAGI Hisako (Tokyo Inst. Technol., Yokohama, JPN) ,  NAKAMURA Nobuhiro (Tokyo Inst. Technol., Yokohama, JPN) ,  SHIGA Yasuhiro (Tokyo Univ. Pharmacy and Life Sci., Tokyo, JPN) ,  OHTA Toshihiro (Tokyo Univ. Pharmacy and Life Sci., Tokyo, JPN) ,  TSUZUKI Mikio (Tokyo Univ. Pharmacy and Life Sci., Tokyo, JPN)
Material： Marine Biotechnology  (Mar Biotechnol)
Volume： 19  Issue： 5  Page： 430-440  Publication year： Sep. 2017 
JST Material Number： W0517B  ISSN： 1436-2228  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *reproduction toxicity ,...
Semi thesaurus term： *developmental toxicity ,...

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JST classification (1)： Toxicity of organic compounds  (GZ02030Y)

Substance index (3)： Ethoxyzolamide ,  Dorzolamide ,  Acetazolamide

Reference (46)：

• Amsterdam A, Nissen RM, Sun Z, Swindell EC, Farrington S, Hopkins N (2004) Identification of 315 genes essential for early zebrafish development. Proc Natl Acad Sci U S A 101:12792-12797
• Aspatwar A, Tolvanen MEE, Jokitalo E, Parikka M, Ortutay C, Harjula SKE, Rämet M, Vihinen M, Parkkila S (2013) Abnormal cerebellar development and ataxia in CARP VIII morphant zebrafish. Hum Mol Genet 22:417-432
• Beier M, Anken R (2006) On the role of carbonic anhydrase in the early phase of fish otolith mineralization. Adv Space Res 38:1119-1122
• Beier M, Hilbig R, Anken R (2008) Histochemical localisation of carbonic anhydrase in the inner ear of developing cichlid fish, Oreochromis mossambicus. Adv Space Res 42:1986-1994
• Brubaker KD, Mao F, Gay CV (1999) Localization of carbonic anhydrase in living osteoclasts with bodipy 558/568-modified acetazolamide, a thiadiazole carbonic anhydrase inhibitor. J Histochem Cytochem 47:545-550

Terms in the title (6)： 炭酸アンヒドラーゼ阻害剤 ,  内耳 ,  ゼブラフィッシュ ,  胚発生 ,  発生毒性 ,  誘導