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J-GLOBAL ID：201702262285559641   Reference number：17A1067818

Ameliorative effect of sansoninto on sleep disturbance and spatial memory impairment in an Alzheimer’s disease rat model

Alzheimer病ラットモデルにおける睡眠障害と空間記憶障害に対する酸棗仁湯の改善効果

Author (11)： Moriyama Hiroshi (Faculty of Pharmaceutical Sciences, Department of Neuropharmacology, Fukuoka University, Fukuoka, Japan) ,  Watanabe Takuya (Faculty of Pharmaceutical Sciences, Department of Neuropharmacology, Fukuoka University, Fukuoka, Japan) ,  Watanabe Takuya (Institute for Aging and Brain Sciences, Fukuoka University, Fukuoka, Japan) ,  Takasaki Kotaro (Faculty of Pharmaceutical Sciences, Department of Neuropharmacology, Fukuoka University, Fukuoka, Japan) ,  Nagao Masaki (Institute for Aging and Brain Sciences, Fukuoka University, Fukuoka, Japan) ,  Kubota Kaori (Faculty of Pharmaceutical Sciences, Department of Neuropharmacology, Fukuoka University, Fukuoka, Japan) ,  Kubota Kaori (Institute for Aging and Brain Sciences, Fukuoka University, Fukuoka, Japan) ,  Katsurabayashi Shutaro (Faculty of Pharmaceutical Sciences, Department of Neuropharmacology, Fukuoka University, Fukuoka, Japan) ,  Egashira Nobuaki (Department of Pharmacy, Kyushu University Hospital, Fukuoka, Japan) ,  Iwasaki Katsunori (Faculty of Pharmaceutical Sciences, Department of Neuropharmacology, Fukuoka University, Fukuoka, Japan) ,  Iwasaki Katsunori (Institute for Aging and Brain Sciences, Fukuoka University, Fukuoka, Japan)
Material： Traditional & Kampo Medicine  (Tradit Kampo Med)
Volume： 4  Issue： 1  Page： 38-45  Publication year： Apr. 2017 
JST Material Number： Y0941B  ISSN： 2053-4515  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *Alzheimer disease ,...
Semi thesaurus term： *Spatial memory disorder ,...

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Author keywords (5)： Alzheimer’s disease ,  Kampo medicine ,  memory impairment ,  sansoninto ,  sleep disturbance

JST classification (2)： Basic neurology  (GN01020W) ,  Basic research of pharmacology of crude drugs  (GX06020J)

Reference (20)：

• Liguori C , Romigi A , Nuccetelli M et al. Orexinergic system dysregulation, sleep impairment, and cognitive decline in Alzheimer disease. JAMA Neurol. 2014; 71: 1498-1505.
• Moran M , Lynch CA , Walsh C , Coen R , Coakley D , Lawlor BA . Sleep disturbance in mild to moderate Alzheimer's disease. Sleep Med. 2005; 6: 347-352.
• Guo Z , Wills P , Viitanen M , Fastbom J , Winblad B . Cognitive impairment, drug use, and the risk of hip fracture in persons over 75 years old: A community-based prospective study. Am. J. Epidemiol. 1998; 148: 887-892.
• Stahl SM , Markowitz JS , Gutterman EM , Papadopoulos G . Co-use of donepezil and hypnotics among Alzheimer's disease patients living in the community. J. Clin. Psychiatry 2003; 64: 466-472.
• Knott V , Mohr E , Mahoney C , Ilivitsky V . Quantitative electroencephalography in Alzheimer's disease: Comparison with a control group, population norms and mental status. J. Psychiatry Neurosci. 2001; 26: 106-116.

Terms in the title (7)： Alzheimer病 ,  ラット ,  モデル ,  睡眠障害 ,  空間記憶障害 ,  酸棗仁湯 ,  改善効果