Art

J-GLOBAL ID：201702263431366240   Reference number：17A0655904

Emergence of TNIK inhibitors in cancer therapeutics

癌治療におけるTNIK阻害剤の出現

Author (2)： Yamada Tesshi (Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo, Japan) ,  Masuda Mari (Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo, Japan)
Material： Cancer Science (Web)  (Cancer Sci (Web))
Volume： 108  Issue： 5  Page： 818-823  Publication year： 2017 
JST Material Number： U0505A  ISSN： 1349-7006  Document type： Article
Article type： 文献レビュー  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *protein kinase ,...
Semi thesaurus term： *cellular signal transduction ,...

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Author keywords (5)： Cancer stem cell ,  colorectal cancer ,  molecular targeted therapy ,  TNIK ,  Wnt signaling

JST classification (5)： Basic oncology in general  (GE02010R) ,  Enzyme in general  (EB09010D) ,  Biological function  (EB03040U) ,  Tumors(=neoplasms)of digestive system  (GH04000D) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (1)： Mebendazole

Reference (74)：

• Kato H, Sobue T, Katanoda K et al. Editorial Board of the Cancer Statistics in Japan. Cancer statistics in Japan 2007. Tokyo: Foundation for Promotion of Cancer Research (FPCF), 2007.
• Okuno K. Surgical treatment for digestive cancer. Current issues - Colon cancer. Dig Surg 2007; 24: 108-14.
• Koutras AK, Starakis I, Kyriakopoulou U et al. Targeted therapy in colorectal cancer: current status and future challenges. Curr Med Chem 2011; 18: 1599-612.
• Omura K. Advances in chemotherapy against advanced or metastatic colorectal cancer. Digestion 2008; 77(Suppl 1): 13-22.
• Grothey A, Van Cutsem E, Sobrero A et al. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet 2013; 381: 303-12.

Terms in the title (2)： 癌治療 ,  TNIK阻害剤