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J-GLOBAL ID：201702264407216296   Reference number：17A0136271

Retention of acetylcarnitine in chronic kidney disease causes insulin resistance in skeletal muscle

慢性腎臓病におけるアセチルカルニチンの保持は骨格筋におけるインスリン抵抗性を発生させる

Author (7)： Miyamoto Yasunori (Department of Internal Medicine, Division of Nephrology, Tokyo Medical University Ibaraki Medical Center) ,  Miyazaki Teruo (Joint Research Center, Tokyo Medical University Ibaraki Medical Center) ,  Honda Akira (Joint Research Center, Tokyo Medical University Ibaraki Medical Center) ,  Honda Akira (Department of Internal Medicine, Division of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center) ,  Shimohata Homare (Department of Internal Medicine, Division of Nephrology, Tokyo Medical University Ibaraki Medical Center) ,  Hirayama Kouichi (Department of Internal Medicine, Division of Nephrology, Tokyo Medical University Ibaraki Medical Center) ,  Kobayashi Masaki (Department of Internal Medicine, Division of Nephrology, Tokyo Medical University Ibaraki Medical Center)
Material： Journal of Clinical Biochemistry and Nutrition  (JCBN)
Volume： 59  Issue： 3  Page： 199-206(J-STAGE)  Publication year： 2016 
JST Material Number： X0851A  ISSN： 0912-0009  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *kidney disease ,...

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Author keywords (5)： chronic kidney disease ,  insulin resistance ,  acetylcarnitine ,  skeletal muscle ,  mitochondria

JST classification (1)： Urogenital diseases  (GM03000L)

Substance index (1)： Acetylcarnitine

Reference (44)：

• 1 Horton ES, Johnson C, Lebovitz HE. Carbohydrate metabolism in uremia. Ann Intern Med 1968; 68: 63-74.
• 2 Becker B, Kronenberg F, Kielstein JT, et al. Renal insulin resistance syndrome, adiponectin and cardiovascular events in patients with kidney disease: the mild and moderate kidney disease study. J Am Soc Nephrol 2005; 16: 1091-1098.
• 3 Hosoya K, Minakuchi H, Wakino S, et al. Insulin resistance in chronic kidney disease is ameliorated by spironolactone in rats and humans. Kidney Int 2015; 87: 749-760.
• 4 DeFronzo RA, Alvestrand A, Smith D, Hendler R, Hendler E, Wahren J. Insulin resistance in uremia. J Clin Invest 1981; 67: 563-568.
• 5 Friedman JE, Dohm GL, Elton CW, et al. Muscle insulin resistance in uremic humans: glucose transport, glucose transporters, and insulin receptors. Am J Physiol 1991; 261 (1 Pt 1): E87-E94.

Terms in the title (4)： 慢性腎臓病 ,  アセチルカルニチン ,  骨格筋 ,  インスリン抵抗性