Art

J-GLOBAL ID：201702265088824368   Reference number：17A0135717

Iron-induced epigenetic abnormalities of mouse bone marrow through aberrant activation of aconitase and isocitrate dehydrogenase

アコニターゼとイソクエン酸デヒドロゲナーゼの異常活性化を通じたマウス骨髄の鉄誘発後成的異常

Author (14)： Yamamoto Masayo (Division of Gastroenterology and Hematology/Oncology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan) ,  Tanaka Hiroki (Department of Gastrointestinal Immunology and Regenerative Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan) ,  Tanaka Hiroki (Department of Legal Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan) ,  Toki Yasumichi (Division of Gastroenterology and Hematology/Oncology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan) ,  Hatayama Mayumi (Division of Gastroenterology and Hematology/Oncology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan) ,  Ito Satoshi (Division of Gastroenterology and Hematology/Oncology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan) ,  Addo Lynda (Division of Gastroenterology and Hematology/Oncology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan) ,  Shindo Motohiro (Division of Gastroenterology and Hematology/Oncology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan) ,  Sasaki Katsunori (Department of Gastrointestinal Immunology and Regenerative Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan) ,  Ikuta Katsuya (Division of Gastroenterology and Hematology/Oncology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan) ,  Ohtake Takaaki (International University of Health and Welfare Hospital, Nasu-shiobara, Tochigi, Japan) ,  Fujiya Mikihiro (Division of Gastroenterology and Hematology/Oncology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan) ,  Torimoto Yoshihiro (Oncology Center, Asahikawa Medical University Hospital, Asahikawa, Hokkaido, Japan) ,  Kohgo Yutaka (International University of Health and Welfare Hospital, Nasu-shiobara, Tochigi, Japan)
Material： International Journal of Hematology  (Int J Hematol)
Volume： 104  Issue： 4  Page： 491-501  Publication year： Oct. 2016 
JST Material Number： F0888A  ISSN： 0925-5710  CODEN： IJHEEY  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *myelodysplastic syndrome ,...
Semi thesaurus term： アコニターゼ1

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Author keywords (4)： Myelodysplastic syndrome ,  Leukemia ,  DNA methylation ,  Iron overload

JST classification (1)： Basic hematology  (GK01020N)

Substance index (1)： 2-Hydroxyglutaric acid

Reference (41)：

• List AF, Sandberg AA, Doll DC. Myelodysplastic Syndromes. In: Greer JP, Foerster J, Lukens JN, Rodgers GM, Paraskevas F, Glader B, editors. Wintrobe’s clinical hematology. 11th ed. Philadlphia: Lippincott Williams & Wilkins; 2004. p. 2207-34.
• Shlush LI, Zandi S, Itzkovitz S, Schuh AC. Aging, clonal hematopoiesis and preleukemia: not just bad luck? Int J Hematol. 2015;102:513-22.
• Takatoku M, Uchiyama T, Okamoto S, Kanakura Y, Sawada K, Tomonaga M, et al. Retrospective nationwide survey of Japanese patients with transfusion-dependent MDS and aplastic anemia highlights the negative impact of iron overload on morbidity/mortality. Eur J Haematol. 2007;78:487-94.
• Neukirchen J, Fox F, Kündgen A, Nachtkamp K, Strupp C, Haas R, et al. Improved survival in MDS patients receiving iron chelation therapy-a matched pair analysis of 188 patients from the Düsseldorf MDS registry. Leuk Res. 2012;36:1067-70.
• Rose C, Brechignac S, Vassilief D, Pascal L, Stamatoullas A, Guerci A, et al. GFM (Groupe Francophone des Myélodysplasies). Does iron chelation therapy improve survival in regularly transfused lower risk MDS patients? A multicenter study by the GFM (Groupe Francophone des Myélodysplasies). Leuk Res. 2010;34:864-70.

Terms in the title (7)： アコニターゼ ,  イソクエン酸デヒドロゲナーゼ ,  活性化 ,  マウス ,  骨髄 ,  鉄 ,  誘発