Art

J-GLOBAL ID：201702265421413410   Reference number：17A1067820

Effect of hachimijiogan on memory impairment induced by beta-amyloid combined with cerebral ischemia in rats

ラットにおける脳虚血と組み合わせたβ-アミロイドにより誘導される記憶障害に対する八味地黄丸の効果

Author (14)： Moriyama Hiroshi (Faculty of Pharmaceutical Sciences, Department of Neuropharmacology, Fukuoka University, Fukuoka, Japan) ,  Mishima Takayasu (Department of Neurology, Fukuoka University School of Medicine, Fukuoka, Japan) ,  Kainuma Mosaburo (Community Medicine Education Unit, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan) ,  Watanabe Takuya (Faculty of Pharmaceutical Sciences, Department of Neuropharmacology, Fukuoka University, Fukuoka, Japan) ,  Watanabe Takuya (AIG Collaborative Research Institute for Aging and Brain Sciences, Fukuoka University, Fukuoka, Japan) ,  Nagao Masaki (AIG Collaborative Research Institute for Aging and Brain Sciences, Fukuoka University, Fukuoka, Japan) ,  Takasaki Kotaro (Faculty of Pharmaceutical Sciences, Department of Neuropharmacology, Fukuoka University, Fukuoka, Japan) ,  Kubota Kaori (Faculty of Pharmaceutical Sciences, Department of Neuropharmacology, Fukuoka University, Fukuoka, Japan) ,  Kubota Kaori (AIG Collaborative Research Institute for Aging and Brain Sciences, Fukuoka University, Fukuoka, Japan) ,  Katsurabayashi Shutaro (Faculty of Pharmaceutical Sciences, Department of Neuropharmacology, Fukuoka University, Fukuoka, Japan) ,  Tsuboi Yoshio (Department of Neurology, Fukuoka University School of Medicine, Fukuoka, Japan) ,  Tsuboi Yoshio (AIG Collaborative Research Institute for Aging and Brain Sciences, Fukuoka University, Fukuoka, Japan) ,  Iwasaki Katsunori (Faculty of Pharmaceutical Sciences, Department of Neuropharmacology, Fukuoka University, Fukuoka, Japan) ,  Iwasaki Katsunori (AIG Collaborative Research Institute for Aging and Brain Sciences, Fukuoka University, Fukuoka, Japan)
Material： Traditional & Kampo Medicine  (Tradit Kampo Med)
Volume： 4  Issue： 1  Page： 51-54  Publication year： Apr. 2017 
JST Material Number： Y0941B  ISSN： 2053-4515  Document type： Article
Article type： 短報  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： rat ,...
Semi thesaurus term： Spatial memory disorder ,...

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Author keywords (3)： Alzheimer’s disease ,  beta-amyloid ,  hachimijiogan

JST classification (3)： Basic research of pharmacology of crude drugs  (GX06020J) ,  Basic neurology  (GN01020W) ,  Basic research of other drugs acting on central nervous system  (GW03120U)

Substance index (1)： Donepezil

Reference (11)：

• Iwasaki K , Kobayashi S , Chimura Y et al. A randomized, double-blind, placebo-controlled clinical trial of the Chinese herbal medicine “ba wei di huang wan” in the treatment of dementia. J. Am. Geriatr. Soc. 2004; 52: 1518-1521.
• Hirokawa S , Nose M , Ishige A , Amagaya S , Oyama T , Ogihara Y . Effect of hachimi-jio-gan on scopolamine-induced memory impairment and on acetylcholine content in rat brain. J. Ethnopharmacol. 1996; 50: 77-84.
• Hirokawa S , Nose M , Ishige A , Amagaya S , Ogihara Y . Effect of hachimijiogan, an oriental herbal medicinal mixture, on experimental amnesia in mice. Biol. Pharm. Bull. 1994; 17: 1182-1186.
• Liu W , Wong A , Law AC , Mok VC . Cerebrovascular disease, amyloid plaques, and dementia. Stroke 2015; 46: 1402-1407.
• Iwasaki K , Egashira N , Hatip-Al-Khatib I et al. Cerebral ischemia combined with beta-amyloid impairs spatial memory in the eight-arm radial maze task in rats. Brain Res. 2006; 1097: 216-223.

Terms in the title (6)： ラット ,  脳虚血 ,  β-アミロイド ,  誘導 ,  記憶障害 ,  八味地黄丸