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J-GLOBAL ID：201702267566008208   Reference number：17A1513465

Treatment with Antiepileptic Agent Perampanel Suppresses Bone Formation and Enhances Bone Resorption: A Bone Histomorphometric Study in Mice

抗癲癇薬ペランパネルによる処理は骨形成を抑制し,骨吸収を増強する:マウスにおける骨組織形態計測研究

Author (9)： Kanda Junkichi (Department of Clinical Pharmacotherapy, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences) ,  Izumo Nobuo (General Health Medical Center, Yokohama University of Pharmacy) ,  Kobayashi Yoshiko (Department of Radiation Science, Yokohama University of Pharmacy) ,  Onodera Kenji (Department of Clinical Pharmacotherapy and Pharmacy, Bethel Epilepsy Centre) ,  Shimakura Taketoshi (Niigata Bone Science Institute) ,  Yamamoto Noriaki (Niigata Bone Science Institute) ,  Yamamoto Noriaki (Division of Orthopedic Surgery, Niigata Rehabilitation Hospital) ,  Takahashi Hideaki E (Niigata Bone Science Institute) ,  Wakabayashi Hiroyuki (Department of Clinical Pharmacotherapy, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences)
Material： Journal of Hard Tissue Biology  (J Hard Tissue Biol)
Volume： 26  Issue： 4  Page： 405-410(J-STAGE)  Publication year： 2017 
JST Material Number： L2839A  ISSN： 1341-7649  CODEN： JHTBFF  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Mus musculus ,...

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Author keywords (5)： Perampanel ,  Bone histomorphometry ,  Osteoclast ,  Osteoblast ,  Mice

JST classification (1)： Basic dentistry(= odontology)  (GT01020O)

Substance index (1)： Perampanel

Reference (18)：

• 1. Browne TR and Holmes GL. Epilepsy. N Engl J Med 344: 1145-1151, 2001
• 2. Mattson RH and Gidal BE. Fractures, epilepsy, and antiepileptic drugs. Epilepsy Behav 5: S36-S40, 2004
• 3. Sheth RD, Gidal BE and Hermann BP. Pathological fractures in epilepsy. Epilepsy Behav 9: 601-605, 2006
• 4. Takahashi A, Onodera K, Shinoda H and Mayanagi H. Phenytoin and its metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin, show bone resorption in cultured neonatal mouse calvaria. Jpn J Pharmacol 82: 82-84, 2000
• 5. Moro-Alvarez MJ, Diaz Curiel M, de la Piedra C, Marinoso ML and Carrascal MT. Bone disease induced by phenytoin therapy: clinical and experimental study. Eur Neurol 62: 219-230, 2009

Terms in the title (9)： 抗癲癇薬 ,  ペランパネル ,  骨形成 ,  骨吸収 ,  増強 ,  マウス ,  骨 ,  組織形態計測 ,  研究