Art

J-GLOBAL ID：201702274716200537   Reference number：17A0601488

Protein kinase A inhibition facilitates the antitumor activity of xanthohumol, a valosin-containing protein inhibitor

プロテインキナーゼA阻害はバロシン含有蛋白質阻害剤であるキサントフモールの抗腫瘍活性を促進する

Author (13)： Shikata Yuki (Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Yokohama, Japan) ,  Yoshimaru Tetsuro (Division of Genome Medicine, Institute for Genome Research, Tokushima University, Tokushima, Japan) ,  Komatsu Masato (Division of Genome Medicine, Institute for Genome Research, Tokushima University, Tokushima, Japan) ,  Katoh Hiroto (Department of Genomic Pathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan) ,  Katoh Hiroto (JST, PRESTO, Saitama, Japan) ,  Sato Reiko (Department of Genomic Pathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan) ,  Kanagaki Shuhei (Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Yokohama, Japan) ,  Okazaki Yasumasa (Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan) ,  Toyokuni Shinya (Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan) ,  Tashiro Etsu (Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Yokohama, Japan) ,  Ishikawa Shumpei (Department of Genomic Pathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan) ,  Katagiri Toyomasa (Division of Genome Medicine, Institute for Genome Research, Tokushima University, Tokushima, Japan) ,  Imoto Masaya (Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Yokohama, Japan)
Material： Cancer Science (Web)  (Cancer Sci (Web))
Volume： 108  Issue： 4  Page： 785-794  Publication year： 2017 
JST Material Number： U0505A  ISSN： 1349-7006  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *Humulus lupulus ,...
Semi thesaurus term： cellular signal transduction ,...

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Author keywords (5)： Adenylate cyclase ,  antitumor activity ,  apoptosis ,  valosin-containing protein ,  xanthohumol

JST classification (3)： Experimental treatment for tumors  (GE02040Y) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Basic research of pharmacology of crude drugs  (GX06020J)

Substance index (1)： Xanthohumol

Reference (34)：

• Power FB, Tutin F, Rogerson H. CXXXV.-The constituents of hops. J Chem Soc Trans 1913; 103: 1267-92.
• Cho Y-C, Kim HJ, Kim Y-J, et al. Differential anti-inflammatory pathway by xanthohumol in IFN-γ and LPS-activated macrophages. Int Immunopharmacol 2008; 8: 567-73.
• Vogel S, Ohmayer S, Brunner G, Heilmann J. Natural and non-natural prenylated chalcones: synthesis, cytotoxicity and anti-oxidative activity. Bioorg Med Chem 2008; 16: 4286-93.
• Albini A, Dell'Eva R, Vené R, et al. Mechanisms of the antiangiogenic activity by the hop flavonoid xanthohumol: NF-κB and Akt as targets. FASEB J 2006; 20: 527-9.
• Bhattacharya S, Virani S, Zavro M, Haas GJ. Inhibition of streptococcus mutans and other oral streptococci by hop (Humulus lupulus L.) constituents. Econ Bot 2003; 57: 118-25.

Terms in the title (7)： プロテインキナーゼA ,  阻害 ,  バロシン含有蛋白質 ,  阻害剤 ,  キサントフモール ,  抗腫瘍活性 ,  促進