Art

J-GLOBAL ID：201702274974125999   Reference number：17A1714296

Enantioselective inhibitory abilities of enantiomers of notoamides against RANKL-induced formation of multinuclear osteoclasts

多核破骨細胞のRANKL誘導形成に対するノトアミドのエナンチオマのエナンチオ選択的阻害能力【Powered by NICT】

Author (10)： Kato Hikaru (Department of Natural Products, Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe-honmachi 5-1, Kumamoto 862-0973, Japan) ,  Kai Aika (Department of Natural Products, Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe-honmachi 5-1, Kumamoto 862-0973, Japan) ,  Kawabata Tetsuro (Department of Natural Products, Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe-honmachi 5-1, Kumamoto 862-0973, Japan) ,  Sunderhaus James D. (Department of Chemistry, Colorado State University, 1301 Center Avenue, Fort Collins, CO 80523, United States) ,  McAfoos Timothy J. (Department of Chemistry, Colorado State University, 1301 Center Avenue, Fort Collins, CO 80523, United States) ,  Finefield Jennifer M. (Department of Chemistry, Colorado State University, 1301 Center Avenue, Fort Collins, CO 80523, United States) ,  Sugimoto Yukihiko (Department of Pharmaceutical Biochemistry, Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe-honmachi 5-1, Kumamoto 862-0973, Japan) ,  Williams Robert M. (Department of Chemistry, Colorado State University, 1301 Center Avenue, Fort Collins, CO 80523, United States) ,  Williams Robert M. (University of Colorado Cancer Center, Aurora, CO 80045, United States) ,  Tsukamoto Sachiko (Department of Natural Products, Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe-honmachi 5-1, Kumamoto 862-0973, Japan)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 27  Issue： 22  Page： 4975-4978  Publication year： 2017 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The marine-derived Aspergillus...

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Thesaurus term： Prenylation ,  *RANKL ,  *enantiomer ,  *osteoclast ,  biological activity ,  indole alkaloid ,  ocean ,  receptor ,  osteoclast cell formation ,  Ligands ,  RAW264 cell ,  terrestrial ,  Aspergillus ,  microorganism ,  Deuteromycetes ,  Hyphomycetes ,  Plectomycetes
Semi thesaurus term： Aspergillus ,  阻害剤 , 【Automatic Indexing@JST】

Author keywords (5)： Notoamide ,  Enantiomer ,  Osteoclastogenesis ,  Aspergillus ,  Fungus

JST classification (1)： Synthesis of drugs  (GV01030F)

Substance index (1)： Stephacidin A

Terms in the title (6)： 破骨細胞 ,  RANKL ,  誘導 ,  エナンチオマ ,  阻害 ,  能力