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J-GLOBAL ID：201702275892865899   Reference number：17A1945696

Molecular mechanisms underlying the pilsicainide-induced stabilization of hERG proteins in transfected mammalian cells

トランスフェクトされた哺乳類細胞におけるhERG蛋白質のピルジカイニド誘導安定化の基礎をなす分子機構

Author (20)： Onohara Takeshi (Division of Organ Regeneration Surgery, Tottori University Faculty of Medicine, Yonago, Japan) ,  Hisatome Ichiro (Division of Regenerative Medicine and Therapeutics, Department of Genetic Medicine and Regenerative Therapeutics, Tottori University Graduate School of Medical Science, Nishichou 36-1, Yonago, Japan) ,  Kurata Yasutaka (Department of Physiology II, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa, Japan) ,  Li Peili (Division of Regenerative Medicine and Therapeutics, Department of Genetic Medicine and Regenerative Therapeutics, Tottori University Graduate School of Medical Science, Nishichou 36-1, Yonago, Japan) ,  Notsu Tomomi (Division of Regenerative Medicine and Therapeutics, Department of Genetic Medicine and Regenerative Therapeutics, Tottori University Graduate School of Medical Science, Nishichou 36-1, Yonago, Japan) ,  Morikawa Kumi (Division of Regenerative Medicine and Therapeutics, Department of Genetic Medicine and Regenerative Therapeutics, Tottori University Graduate School of Medical Science, Nishichou 36-1, Yonago, Japan) ,  Otani Naoyuki (Department of Pharmacology, Dokkyo Medical College, Tochigi, Japan) ,  Yoshida Akio (Division of Regenerative Medicine and Therapeutics, Department of Genetic Medicine and Regenerative Therapeutics, Tottori University Graduate School of Medical Science, Nishichou 36-1, Yonago, Japan) ,  Iitsuka Kazuhiko (Division of Cardiovascular Medicine, Department of Molecular Medicine and Therapeutics, Faculty of Medicine, Tottori University, Nishichou 36-1, Yonago, Japan) ,  Kato Masaru (Division of Cardiovascular Medicine, Department of Molecular Medicine and Therapeutics, Faculty of Medicine, Tottori University, Nishichou 36-1, Yonago, Japan) ,  Miake Junichiro (Division of Cardiovascular Medicine, Department of Molecular Medicine and Therapeutics, Faculty of Medicine, Tottori University, Nishichou 36-1, Yonago, Japan) ,  Ninomiya Haruaki (Department of Biological Regulation, Tottori University Faculty of Medicine, Nishichou 36-1, Yonago, Japan) ,  Higaki Katsumi (Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University, Nishichou 36-1, Yonago, Japan) ,  Shirayoshi Yasuaki (Division of Regenerative Medicine and Therapeutics, Department of Genetic Medicine and Regenerative Therapeutics, Tottori University Graduate School of Medical Science, Nishichou 36-1, Yonago, Japan) ,  Nishihara Takashi (Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4-101 Koyama-minami, Tottori 680-8552, Japan) ,  Nishihara Takashi (Center for Research on Green Sustainable Chemistry, Tottori University, 4-101 Koyama-minami, Tottori 680-8552, Japan) ,  Itoh Toshiyuki (Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4-101 Koyama-minami, Tottori 680-8552, Japan) ,  Itoh Toshiyuki (Center for Research on Green Sustainable Chemistry, Tottori University, 4-101 Koyama-minami, Tottori 680-8552, Japan) ,  Nakamura Yoshinobu (Division of Organ Regeneration Surgery, Tottori University Faculty of Medicine, Yonago, Japan) ,  Nishimura Motonobu (Division of Organ Regeneration Surgery, Tottori University Faculty of Medicine, Yonago, Japan)
Material： Journal of Arrhythmia (Web)
Volume： 33  Issue： 3  Page： 226-233  Publication year： 2017 
JST Material Number： U1150A  ISSN： 1880-4276  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： cultured cell ,...
Semi thesaurus term： Akt/protein kinase B ,...

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Author keywords (3)： Pilsicainide ,  hERG ,  Chemical chaperone

JST classification (2)： Basic research of cardioactive drugs  (GW07020N) ,  Basic medicine on cardiovascular system  (GJ01020K)

Substance index (1)： Pilzicainide

Reference (21)：

• Sanguinetti MC, Jiang C, Curran ME, Keating MT. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell 1995;81:299-307.
• Surawicz B. Electrophysiologic substrate of torsade de pointes: dispersion of repolarization or early afterdepolarizations? J Am Coll Cardiol 1989;14:172-84.
• Li P, Ninomiya H, Kurata Y, et al. Reciprocal control of hERG stability by hsp70 and hsc70 with implication for restoration of LQT2 mutant stability. Circ Res 2011;108:458-68.
• Gordo-Gilart R, Andueza S, Hierro L, Jara P, Alvarez L. Functional rescue of trafficking-impaired ABCB4 mutants by chemical chaperones. PLoS One 2016;11:e0150098.
• Zhang KP, Yang BF, Li BX. Translational toxicology and rescue strategies of the hERG channel dysfunction: biochemical and molecular mechanistic aspects. Acta Pharmacol Sin 2014;35:1473-84.

Terms in the title (8)： 哺乳類細胞 ,  HERG ,  蛋白質 ,  ピルジカイニド ,  誘導 ,  安定化 ,  基礎 ,  分子機構