Art

J-GLOBAL ID：201702277343312969   Reference number：17A1475187

The Aldosterone Receptor Antagonist Eplerenone Inhibits Isoproterenol-Induced Collagen-I and 11β-HSD1 Expression in Rat Cardiac Fibroblasts and the Left Ventricle

アルドステロン受容体拮抗薬エプレレノンはラットの心臓線維芽細胞および左心室におけるイソプロテレノール誘発性のコラーゲン-Iおよび11β-HSD1発現を阻害する

Author (7)： Hori Yasutomo (Laboratory of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University) ,  Touei Daisuke (Laboratory of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University) ,  Saitoh Ryuta (Laboratory of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University) ,  Yamagishi Maki (Laboratory of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University) ,  Kanai Kazutaka (Laboratory of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University) ,  Hoshi Fumio (Laboratory of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University) ,  Itoh Naoyuki (Laboratory of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 40  Issue： 10  Page： 1716-1723(J-STAGE)  Publication year： 2017 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： steroid hormone receptor ,...
Semi thesaurus term： 11beta-HSD1 ,...

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Author keywords (12)： aldosterone ,  beta-adrenoceptor ,  cardiac fibrosis ,  collagen ,  eplerenone ,  fibroblast ,  aldosterone ,  beta-adrenoceptor ,  cardiac fibrosis ,  collagen ,  eplerenone ,  fibroblast

JST classification (2)： Basic medicine on cardiovascular system  (GJ01020K) ,  Basic research of cardioactive drugs  (GW07020N)

Substance index (2)： Isoproterenol ,  Eplerenone

Reference (37)：

• 1) Brum PC, Rolim NP, Bacurau AV, Medeiros A. Neurohumoral activation in heart failure: the role of adrenergic receptors. An. Acad. Bras. Cienc., 78, 485-503 (2006).
• 2) Floras JS. Sympathetic nervous system activation in human heart failure: clinical implications of an updated model. J. Am. Coll. Cardiol., 54, 375-385 (2009).
• 3) Swedberg K, Eneroth P, Kjekshus J, Wilhelmsen L. Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality. CONSENSUS Trial Study Group. Circulation, 82, 1730-1736 (1990).
• 4) Hori Y, Yoshioka K, Kanai K, Hoshi F, Itoh N, Higuchi S-I. Spironolactone decreases isoproterenol-induced ventricular fibrosis and matrix metalloproteinase-2 in rats. Biol. Pharm. Bull., 34, 61-65 (2011).
• 5) Qin W, Rudolph AE, Bond BR, Rocha R, Blomme EA, Goellner JJ, Funder JW, McMahon EG. Transgenic model of aldosterone-driven cardiac hypertrophy and heart failure. Circ. Res., 93, 69-76 (2003).

Terms in the title (11)： アルドステロン受容体 ,  拮抗薬 ,  エプレレノン ,  ラット ,  心臓線維芽細胞 ,  左心室 ,  イソプロテレノール ,  コラーゲン ,  11β-HSD1 ,  発現 ,  阻害