Art

J-GLOBAL ID：201702277791098596   Reference number：17A1692860

Enhancement of bactericidal activity against group B streptococci with reduced penicillin susceptibility by uptake of gentamicin into cells resulting from combination with β-lactam antibiotics

β-ラクタム抗生物質と組み合わせた細胞へのゲンタマイシンの取り込みによるペニシリン感受性の低下したB群連鎖球菌に対する殺菌活性の増強

Author (10)： Ebara Yoshifumi (Department of Laboratory Medicine, Keio University, School of Medicine, Tokyo, Japan) ,  Ebara Yoshifumi (Department of Infectious Diseases, Keio University, School of Medicine, Tokyo, Japan) ,  Morozumi Miyuki (Department of Infectious Diseases, Keio University, School of Medicine, Tokyo, Japan) ,  Sato Mamiko (Laboratory of Electron Microscopy, Japan Women’s University, Tokyo, Japan) ,  Moritoki Nobuko (Laboratory of Electron Microscopy, Japan Women’s University, Tokyo, Japan) ,  Toyofuku Meiwa (Department of Pediatrics, Yokohama Rosai Hospital, Yokohama, Japan) ,  Takata Misako (Department of Infectious Diseases, Keio University, School of Medicine, Tokyo, Japan) ,  Murata Mitsuru (Department of Laboratory Medicine, Keio University, School of Medicine, Tokyo, Japan) ,  Ubukata Kimiko (Department of Infectious Diseases, Keio University, School of Medicine, Tokyo, Japan) ,  Iwata Satoshi (Department of Infectious Diseases, Keio University, School of Medicine, Tokyo, Japan)
Material： Journal of Infection and Chemotherapy  (J Infect Chemother)
Volume： 23  Issue： 5  Page： 312-318  Publication year： May. 2017 
JST Material Number： L2852A  ISSN： 1341-321X  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *Streptococcus pyogenes ,...
Semi thesaurus term： *gentamicin ,...

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Author keywords (6)： Reduced penicillin susceptibility ,  Streptococcus agalactiae ,  Group B streptococci ,  Antibiotic combinations ,  Bactericidal effect ,  Synergistic effect

JST classification (1)： Basic research of antibiotics acting on pathogenic organisms  (GX05020C)

Substance index (2)： Ampicillin ,  Cefotaxime

Reference (36)：

• Schuchat A. Epidemiology of group B streptococcal disease in the United States: shifting paradigms. Clin Microbiol Rev 1998;11:497-513.
• Phares CR, Lynfield R, Farley MM, Mohie-Boetani J, Harrison LH, Petit S, et al. Epidemiology of invasive group B streptococcal disease in the United States, 1999-2005. JAMA 2008;299:2056-65.
• Jordan HT, Farley MM, Craig A, Mohie-Boetani J, Harrison LH, Petit S, et al. Revisiting the need for vaccine prevention of late-onset neonatal group B streptococcal disease. Pediatr Infect Dis J 2008;27:1057.
• Thigpen MC, Whitney CG, Messonnier NE, Zell ER, Lynfield R, Hadler JL, et al. Bacterial meningitis in the United States, 1998-2007. N Engl J Med 2011;364: 2016-25.
• Edmond KM, Kortsalioudaki C, Scott 5, Schrag S, Zaidi AKM, Cousens S, et al. Group B streptococcal disease in infants aged younger than 3 months: systematic review and meta-analysis. Lancet 2012;379:547-56.

Terms in the title (9)： ラクタム抗生物質 ,  細胞 ,  ゲンタマイシン ,  取り込み ,  ペニシリン ,  感受性 ,  B群連鎖球菌 ,  殺菌活性 ,  増強