Art

J-GLOBAL ID：201702278391653116   Reference number：17A0816494

Apelin protects against NMDA-induced retinal neuronal death via an APJ receptor by activating Akt and ERK1/2, and suppressing TNF-α expression in mice

アペリンはマウスにおいてAPJ受容体を介してAktとERK1/2を活性化し,TNF-α発現を抑制することによりNMDA(N-メチル-D-アスパラギン酸)誘発性網膜神経細胞死を防止する

Author (7)： Ishimaru Yuki (Department of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotouge-cho, Hirakata, Osaka 573-0101, Japan) ,  Sumino Akihide (Department of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotouge-cho, Hirakata, Osaka 573-0101, Japan) ,  Kajioka Daiki (Department of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotouge-cho, Hirakata, Osaka 573-0101, Japan) ,  Shibagaki Fumiya (Department of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotouge-cho, Hirakata, Osaka 573-0101, Japan) ,  Yamamuro Akiko (Department of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotouge-cho, Hirakata, Osaka 573-0101, Japan) ,  Yoshioka Yasuhiro (Department of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotouge-cho, Hirakata, Osaka 573-0101, Japan) ,  Maeda Sadaaki (Department of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotouge-cho, Hirakata, Osaka 573-0101, Japan)
Material： Journal of Pharmacological Sciences (Web)  (J Pharmacol Sci (Web))
Volume： 133  Issue： 1  Page： 34-41  Publication year： 2017 
JST Material Number： U0667A  ISSN： 1347-8613  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *bioactive peptide ,...
Semi thesaurus term： Akt ,...

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Author keywords (5)： Apelin ,  APJ ,  Knockout mouse ,  Neuroprotection ,  Retina

JST classification (4)： Bioactive peptides  (EB08100U) ,  Cell physiology in general  (EF02010S) ,  Drug therapy(=pharmacotherapy)for eye diseases  (GP05020E) ,  Drugs acting on nervous system in general  (GW02000I)

Substance index (1)： NMDA

Reference (33)：

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• Tatemoto K, Hosoya M, Habata Y, Fujii R, Kakegawa T, Zou M, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun. 1998;251:471-476.
• Hosoya M, Kawamata Y, Fukusumi S, Fujii R, Habata Y, Hinuma S, et al. Molecular and functional characteristics of APJ. Tissue distribution of mRNA and interaction with the endogenous ligand apelin. J Biol Chem. 2000;275: 21061-21067.

Terms in the title (11)： アペリン ,  マウス ,  APJ受容体 ,  Akt ,  ERK1 ,  活性化 ,  TNF-α ,  発現 ,  NMDA ,  N-メチル-D-アスパラギン酸 ,  網膜神経細胞