Art

J-GLOBAL ID：201702283137822050   Reference number：17A0359958

Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β-catenin signaling pathway

セレコキシブおよび2,5-ジメチルセレコキシブはWnt/β-カテニンシグナリング経路の抑制により腸癌増殖を阻害する

Author (13)： Egashira Issei (Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan) ,  Egashira Issei (Department of Medicine and Clinical Science, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan) ,  Takahashi-Yanaga Fumi (Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan) ,  Takahashi-Yanaga Fumi (Global Medical Science Education Unit, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan) ,  Nishida Risa (Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan) ,  Arioka Masaki (Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan) ,  Igawa Kazunobu (Department of Molecular and Material Science, Institute for Materials Chemistry and Engineering, Kyushu University, Kasuga, Japan) ,  Tomooka Katsuhiko (Department of Molecular and Material Science, Institute for Materials Chemistry and Engineering, Kyushu University, Kasuga, Japan) ,  Nakatsu Yoshimichi (Department of Medical Biophysics and Radiation Biology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan) ,  Tsuzuki Teruhisa (Department of Medical Biophysics and Radiation Biology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan) ,  Nakabeppu Yusaku (Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan) ,  Kitazono Takanari (Department of Medicine and Clinical Science, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan) ,  Sasaguri Toshiyuki (Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan)
Material： Cancer Science (Web)  (Cancer Sci (Web))
Volume： 108  Issue： 1  Page： 108-115  Publication year： 2017 
JST Material Number： U0505A  ISSN： 1349-7006  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *non-steroidal anti-inflammatory agent ,...
Semi thesaurus term： Wnt signaling ,...

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Author keywords (5)： 25-dimethylcelecoxib ,  celecoxib ,  colon cancer ,  TCF7L2 ,  Wnt/β-catenin signaling pathway

JST classification (3)： Experimental treatment for tumors  (GE02040Y) ,  Tumors(=neoplasms)of digestive system  (GH04000D) ,  Basic research of anti-inflammatory drugs  (GW15010T)

Substance index (1)： Celecoxib

Reference (45)：

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• Grösch S, Maier TJ, Schiffmann S, Geisslinger G. Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 inhibitors. J Natl Cancer Inst 2006; 98: 736-47.
• Thun MJ, Henley SJ, Patrono C. Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues. J Natl Cancer Inst 2002; 94: 252-66.
• Giardiello FM, Hamilton SR, Krush AJ et al. Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. N Engl J Med 1993; 328: 1313-6.

Terms in the title (8)： セレコキシブ ,  Wnt ,  β-カテニン ,  シグナリング ,  経路 ,  腸癌 ,  増殖 ,  阻害