Art

J-GLOBAL ID：201702283326268533   Reference number：17A0987888

LC-MS/MS and chiroptical spectroscopic analyses of multidimensional metabolic systems of chiral thalidomide and its derivatives

キラルサリドマイドおよびその誘導体の多次元代謝系のLC-MS/MSとキロプチカル分光学的分析【Powered by NICT】

Author (4)： Ogino Yoshiyuki (Waseda University, Department of Life Science and Medical Bioscience, Tokyo, Japan) ,  Tanaka Masahito (National Institute of Advanced Industrial Science and Technology (AIST), Research Institute of Instrumentation Frontier, Tsukuba, Japan) ,  Shimozawa Togo (Waseda University, Department of Life Science and Medical Bioscience, Tokyo, Japan) ,  Asahi Toru (Waseda University, Department of Life Science and Medical Bioscience, Tokyo, Japan)
Material： Chirality
Volume： 29  Issue： 6  Page： 282-293  Publication year： 2017 
JST Material Number： W0179A  ISSN： 0899-0042  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Enantiomeric thalidomide under...

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Thesaurus term： enzyme ,  hydroxylation ,  Biotransformation ,  *higher dimension ,  oxidation ,  in vitro experiment ,  spectroscopy ,  metabolite ,  *Metabolism ,  Hydrolysis ,  time dependence ,  network ,  *chirality ,  *liquid chromatography-tandem mass spectrometry ,  aromatic carboxylic acid ,  immunotherapeutic drug ,  acid imide ,  polynuclear aromatic compound ,  dicarboxylic acid
Semi thesaurus term： *LC/MS/MS , 【Automatic Indexing@JST】

Author keywords (6)： chiral inversion ,  chiroptical spectroscopy ,  enzymatic hydroxylation ,  hydrolysis ,  LC-MS/MS ,  thalidomide

JST classification (5)： Gevmetry of molecules in general  (BH05021S) ,  Polymer carrier,catalytic reaction  (CG03030W) ,  Triazoles  (CF07084O) ,  Stereochemistry of polymers  (CG02031G) ,  Proteins and peptides in general  (EB03010N)

Substance index (1)： Thalidomide

Terms in the title (6)： 誘導体 ,  多次元 ,  代謝系 ,  LC-MS ,  分光学 ,  分析