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J-GLOBAL ID：201702283471797072   Reference number：17A0088293

CpG island methylator phenotype is associated with the efficacy of sequential oxaliplatin- and irinotecan-based chemotherapy and EGFR-related gene mutation in Japanese patients with metastatic colorectal cancer

転移性結腸直腸癌の日本人患者において,CpGアイランドメチル化形質は,オキサリプラチンベース-イリノテカンベース併用化学療法の有効性とEGFR関連遺伝子突然変異に関係している

Author (17)： Zhang Xiaofei (Tohoku University) ,  Shimodaira Hideki (Tohoku University) ,  Shimodaira Hideki (Tohoku University Hospital) ,  Soeda Hiroshi (Tohoku University) ,  Soeda Hiroshi (Tohoku University Hospital) ,  Komine Keigo (Tohoku University) ,  Komine Keigo (Tohoku University Hospital) ,  Takahashi Hidekazu (Tohoku University) ,  Ouchi Kota (Tohoku University) ,  Inoue Masahiro (Tohoku University) ,  Inoue Masahiro (Tohoku University Hospital) ,  Takahashi Masanobu (Tohoku University) ,  Takahashi Masanobu (Tohoku University Hospital) ,  Takahashi Shin (Tohoku University) ,  Takahashi Shin (Tohoku University Hospital) ,  Ishioka Chikashi (Tohoku University) ,  Ishioka Chikashi (Tohoku University Hospital)
Material： International Journal of Clinical Oncology  (Int J Clin Oncol)
Volume： 21  Issue： 6  Page： 1091-1101  Publication year： Dec. 2016 
JST Material Number： L3966A  ISSN： 1341-9625  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *colonic neoplasm ,...
Semi thesaurus term： *colorectal cancer ,...

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Author keywords (6)： CpG island methylator phenotype ,  Irinotecan- and oxaliplatin-based chemotherapy ,  Metastatic colorectal cancer ,  Anti-EGFR antibody ,  RAS ,  BRAF

JST classification (1)： Drug therapy(=pharmacotherapy)for tumors  (GE03032C)

Substance index (1)： Irinotecan

Reference (29)：

• Bonasio R, Tu S, Reinberg D (2010) Molecular signals of epigenetic states. Science 330:612-616
• Sharma S, Kelly TK, Jones PA (2010) Epigenetics in cancer. Carcinogenesis 31:27-36
• van Engeland M, Derks S, Smits KM et al (2011) Colorectal cancer epigenetics: complex simplicity. J Clin Oncol 29:1382-1391
• Esteller M (2008) Epigenetics in cancer. N Engl J Med 358:1148-1159
• Weisenberger DJ, Siegmund KD, Campan M et al (2006) CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet 38:787-793

Terms in the title (9)： 転移性結腸直腸癌 ,  日本人 ,  患者 ,  CpGアイランドメチル化形質 ,  オキサリプラチン ,  イリノテカン ,  併用化学療法 ,  有効性 ,  EGFR