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J-GLOBAL ID：201702283898792493   Reference number：17A1378603

X-ray structure of a protease-resistant mutant form of human galectin-9 having two carbohydrate recognition domains with a metal-binding site

金属結合部位を有する2炭水化物認識ドメインを持つヒトのガレクチン-9のプロテアーゼ耐性変異体のX線構造【Powered by NICT】

Author (8)： Yoshida Hiromi (Life Science Research Center and Faculty of Medicine, Kagawa University, 1750-1, Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan) ,  Nishi Nozomu (Life Science Research Center and Faculty of Medicine, Kagawa University, 1750-1, Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan) ,  Wada Kenji (Department of Chemistry for Medicine, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan) ,  Nakamura Takanori (Department of Endocrinology, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan) ,  Hirashima Mitsuomi (Department of Immunology and Immunopathology, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan) ,  Kuwabara Naoyuki (Structural Biology Research Center, Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization (KEK), 1-1 Oho, Tsukuba, Ibaraki 305-0801, Japan) ,  Kato Ryuichi (Structural Biology Research Center, Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization (KEK), 1-1 Oho, Tsukuba, Ibaraki 305-0801, Japan) ,  Kamitori Shigehiro (Life Science Research Center and Faculty of Medicine, Kagawa University, 1750-1, Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 490  Issue： 4  Page： 1287-1293  Publication year： 2017 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Galectin-9 (G9) is a tandem-re...

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Thesaurus term： metal ion ,  *lectin ,  *peptide bond hydrolase ,  interface (surface) ,  thermal stability ,  hydrogen bond ,  *human ,  hydrophobic interaction ,  linker ,  spatial layout ,  glycan ,  C-terminal side ,  *Galectins ,  *X-ray structure ,  *galectin9

Author keywords (5)： Carbohydrate recognition domain ,  Galectin-9 ,  Lectin ,  Tandem-repeat type galectin ,  X-ray structure

JST classification (3)： Cell components in general  (EF03010Z) ,  Biological function  (EB03040U) ,  Cell physiology in general  (EF02010S)

Terms in the title (8)： 結合部位 ,  炭水化物 ,  ドメイン ,  ヒト ,  ガレクチン ,  プロテアーゼ ,  耐性変異 ,  X線構造