Art

J-GLOBAL ID：201702288543775712   Reference number：17A0963901

The flavonoid derivative 4′-nitro-6-hydroxyflavone suppresses the activity of HNF4α and stimulates the degradation of HNF4α protein through the activation of AMPK

フラボノイド誘導体4 ́-ニトロ-6-ヒドロキシフラボンはHNF4αの活性を抑制し,AMPKの活性化を介してHNF4αプロテインの分解を刺激する

Author (4)： INOUE Jun (Univ. Tokyo, Tokyo, JPN) ,  IKEDA Shiori (Univ. Tokyo, Tokyo, JPN) ,  KANAYAMA Tomohiko (Univ. Tokyo, Tokyo, JPN) ,  SATO Ryuichiro (Univ. Tokyo, Tokyo, JPN)
Material： Bioscience, Biotechnology, and Biochemistry  (Bioscience Biotechnology & Biochemistry)
Volume： 81  Issue： 8  Page： 1548-1552  Publication year： Aug. 2017 
JST Material Number： G0021A  ISSN： 0916-8451  CODEN： BBBIEJ  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *DNA binding protein ,...
Semi thesaurus term： *AMPK ,...

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JST classification (2)： Gene expression  (EC02040Q) ,  Condensed derivatives of pyrane  (CF07093I)

Substance index (1)： 6-Hydroxy-2-(4-nitrophenyl)-4H-1-benzopyran-4-one

Reference (20)：

• Sladek FM, Zhong WM, Lai E, et al. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev. 1990;4:2353-2365.
• Gonzalez FJ. Regulation of hepatocyte nuclear factor 4 alpha-mediated transcription. Drug Metab Pharmacokinet. 2008;23:2-7.
• Hayhurst GP, Lee YH, Lambert G, et al. Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol Cell Biol. 2001;21:1393-1403.
• Yoon JC, Puigserver P, Chen G, et al. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature. 2001;413:131-138.
• Zhang BB, Zhou G, Li C. AMPK: an emerging drug target for diabetes and the metabolic syndrome. Cell Metab. 2009;9:407-416.

Terms in the title (10)： フラボノイド ,  誘導体 ,  6-ヒドロキシフラボン ,  HNF4α ,  活性 ,  AMPK ,  活性化 ,  プロテイン ,  分解 ,  刺激