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J-GLOBAL ID：201702290884297082   Reference number：17A1545775

The anti-tumor activity of the STAT3 inhibitor STX-0119 occurs via promotion of tumor-infiltrating lymphocyte accumulation in temozolomide-resistant glioblastoma cell line

STAT3阻害剤STX0119の抗腫瘍活性はテモゾロミド耐性神経膠芽腫細胞株における腫瘍浸潤リンパ球蓄積の促進を介して起こる【Powered by NICT】

Author (15)： Akiyama Yasuto (Immunotherapy Division, Shizuoka Cancer Center Research Institute, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan) ,  Akiyama Yasuto (Division of Neurosurgery, Shizuoka Cancer Center Hospital, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan) ,  Nonomura Chizu (Immunotherapy Division, Shizuoka Cancer Center Research Institute, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan) ,  Ashizawa Tadashi (Immunotherapy Division, Shizuoka Cancer Center Research Institute, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan) ,  Iizuka Akira (Immunotherapy Division, Shizuoka Cancer Center Research Institute, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan) ,  Kondou Ryota (Immunotherapy Division, Shizuoka Cancer Center Research Institute, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan) ,  Miyata Haruo (Immunotherapy Division, Shizuoka Cancer Center Research Institute, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan) ,  Sugino Takashi (Division of Pathology, Shizuoka Cancer Center Hospital, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan) ,  Mitsuya Koichi (Division of Neurosurgery, Shizuoka Cancer Center Hospital, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan) ,  Hayashi Nakamasa (Division of Neurosurgery, Shizuoka Cancer Center Hospital, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan) ,  Nakasu Yoko (Division of Neurosurgery, Shizuoka Cancer Center Hospital, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan) ,  Asai Akira (Graduate School of Pharmaceutical Sciences, University of Shizuoka, Yada 52-1, Suruga-ku, Shizuoka, 422-8526, Japan) ,  Ito Mamoru (Research Division, Central Institute for Experimental Animals, Kawasaki-ku, Kawasaki, Kanagawa 210-0821, Japan) ,  Kiyohara Yoshio (Division of Dermatology, Shizuoka Cancer Center Hospital, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan) ,  Yamaguchi Ken (Office of the President, Shizuoka Cancer Center Hospital, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan)
Material： Immunology Letters  (Immunol Lett)
Volume： 190  Page： 20-25  Publication year： 2017 
JST Material Number： E0738B  ISSN： 0165-2478  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： STAT3 is considered to be a ke...

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Thesaurus term： gene ,  cytokine ,  Immunotherapy ,  *tumor ,  nude mouse ,  macrophage ,  immunosuppression ,  *antitumor action ,  human ,  tumor cell ,  mouse model ,  NOG mouse ,  immune cell ,  *STAT3 Transcription Factor ,  reaction ,  immune response ,  suppression and control
Semi thesaurus term： *STAT3阻害剤 , 【Automatic Indexing@JST】

Author keywords (5)： Humanized NOG mouse ,  NOG-MHC dKO mouse ,  STAT3 inhibitor ,  Tumor-infiltrating lymphocytes ,  TMZ-resistant glioblastoma

JST classification (1)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Terms in the title (9)： STAT3阻害剤 ,  抗腫瘍活性 ,  テモゾロミド ,  耐性 ,  神経膠芽腫 ,  細胞株 ,  腫瘍浸潤リンパ球 ,  蓄積 ,  促進