Kazuki Yasuhiro

2020 - 2023 Generation of humanized rats expressing multiple drug-metabolizing enzyme-related genes using mammalian artificial chromosome technologies

2019 - 2022 Development of induciblydiversified antibody-expressing cell library that enables antibody phenotypic screening

2017 - 2020 Production of genetically modified pigs by combined techniques of chromosome engineering and genome editing

2015 - 2020 Generation of humanized rats expressing drug-metabolizing enzyme using human artificial chromosome and genome editing technologies

2014 - 2017 Development of rapid system for generation of consomic mice via chromosome transfer and elimination technologies

2013 - 2016 Establishment of in vitro and in vivo models for human CES which promote rational development of ester-based prodrugs

2011 - 2013 Study for sex differences of CYP3A enzymes using trans-chromosomic mice containing a human CYP3A gene cluster

2009 - 2012 Creation of CYP3A- and P-glycoprotein-humanized mouse and its application to the study of drug metabolism and disposition

2010 - 2011 Development of the antibody drug production system using a highly efficient artificial chromosome vector.

2009 - 2011 Gene therapy of Duchenne muscular dystrophy using own stem cells and human artificial chromosome

2010 - 2010 iPS細胞とヒト人工染色体ベクターを用いた毛細血管拡張性運動失調症の遺伝子治療

2009 - 2010 スティーブンス・ジョーンソン症候群モデルマウス創製の試み

2007 - 2009 Generation of gene therapy method for ataxia-telangiectasia using a human artificial chromosome

2006 - 2008 Construction of human artificial chromosome for gene therapy of Duchenne muscular dystrophy

2003 - 2004 ヒト21番染色体移入によるダウン症候群モデルマウスの作製と解析