Akaike Takaaki

2023 - 2026 超硫黄分子の代謝制御メカニズムの解明

2021 - 2026 Management of international relation and facility for promotion of research on sulfur biology

2021 - 2026 定量的超硫黄オミックス・イメージング技術の開発と標準化プロトコールの確立

2022 - 2025 硫黄生物学から紐解く膵癌難治化機構の解明と治療応用

2022 - 2025 Study on the role of sulfur respiration in homeostasis and disruption of the skeletal system under hypoxic conditions

2022 - 2025 呼気オミックスを用いた乳がん口腔支援システムの開発

2022 - 2025 Elucidation of new adipocyte functions controlled by sulfur respiration

2022 - 2025 硫黄生物学から紐解く膵癌難治化機構の解明と治療応用

2020 - 2025 超硫黄フラックス解析基盤の創出による筋頑健性構築

2022 - 2024 新しい生体超分子S8環八超硫黄の発見と生理機能解明

2021 - 2024 The study on the role of reactive sulfur species in the pathogenesis of periodontitis

2018 - 2023 Sulfur-mediated energy metabolism, sulfur respiration: Its discovery and physiological functions

2020 - 2022 Remodeling of reactive sulfur metabolism by reactive oxygen species-producing enzyme, Nox: Discovery of reactive sulfur remodelase

2019 - 2022 Regulation of bone remodeling by reactive sulfur species, the novel signal molecules

2017 - 2022 Life science basis of short-lived reactive species originated from foods

2018 - 2021 Pathogenesis of NRF2-addicted cancers

2018 - 2019 Sulfur-dependent energy metabolism: sulfur respiration and its physiological role

2017 - 2019 Redox signal regulation via protein polysulfidation

2017 - 2019 An in vitro study of reactive sulfur species for treatment of cartilage diseases

2016 - 2019 A novel model for causing senescence via mitochondrial dysfunction by environmental factors

2015 - 2019 Promotion of oxygen biology on the basis of international networks

2014 - 2019 Oxygen biology: a new criterion for integrated understanding of life

2014 - 2019 Polysulfur metabolome and regulation of anti-oxidative stress responses

2016 - 2018 Study of the mechanism of biosynthesis of polysulfurated proteins coupled with translation

2015 - 2018 Molecular mechanisms for metabolisms of bacterial reactive sulfur species: implication in antibacterial resistance

2015 - 2018 On the regulatory mechanism of hard tissue metabolism by 8-nitro-cGMP

2013 - 2018 Comprehensive study on environmental electrophiles-mediated signal transduction pathways regulated by reactive sulfur species

2014 - 2016 Analysis of intarocular antioxidant and development of intraocular irrigating solution

2014 - 2016 Novel signaling pathway of bacterial stress responses and host defense via autophagy

2013 - 2016 Ameliorating effects of nitric oxide and/or hydrogen gas inhalation on ARDS

2013 - 2016 Mechanism of intracellular formation of cysteine polysulfide and reactive oxygen species signaling

2012 - 2015 Regulatory mechanisms of redox signal transduction mediated by endogenous electrophiles

2008 - 2014 Signaling Functions of Reactive Oxygen Species

2008 - 2013 Signaling functions of reactive oxygen species

2008 - 2013 Molecular regulation of ROS signal receptor proteins: S-guanylation proteomics

2011 - 2013 エンドトキシンショックにおける新規環状ヌクレオチド : ニトロcGMPのシグナル制御

2011 - 2012 Regulation mechanism by hydrogen sulfide anion of electrophilesignaling

2009 - 2011 Detection and measurement of transthyretin with oxidative modification as a biomarker for disease prevention

2009 - 2011 Involvement of oxidative stress in the pathogenesis of ARDS associated with viral pneumonia

2009 - 2011 Molecular mechanism of signal transduction by reactive oxygen species

2009 - 2010 新興感染症菌ヘリコバクターシネディの感染病態と動脈硬化・心疾患との関連性の解析

2007 - 2010 Academic project of oncogenic factors in malignant tumors and the related diseases in northeast China

2008 - 2008 感染防御におけるNOの新規シグナル伝達機構の解明

2007 - 2008 Involvement of nitrative stress due to influenza virus infection on the pathogenesis and progression of interstitial pneumonias

2007 - 2008 Mechanism of glutathione-mediated regulation of nitrative signal in cells

2007 - 2008 Biological formation of 8-nitroguanosine 3'5'-cyclic monophosphate and its implication in NO signaling

2006 - 2008 Application of functional recombinant HSAs as a DDS carrier

2006 - 2007 Functional analysis of nitric oxide metabolites in hard tissues

2005 - 2007 EPR効果に基づく活性酸素生成型高分子薬の固形癌ターゲティング療法

2005 - 2007 The pathophysiology of malignant glioma and treatment strategies

2005 - 2007 Oxidative stress regulation through NO-induced nucleic acid nitration in pulmonary diseases

2005 - 2007 Molecular mechanisms of nitric oxide-dependent modification and regulation of genome functions

2005 - 2006 Mechanism of Apoptosis Induction by Bacterial Proteases and Its Implication for Bacterial Pathogenesis.

2004 - 2006 Experimental and Clinical Studies on the Significance of Endothelium-Derived Hyperpolarizing Factor (EDHF)

2003 - 2006 Molecular regulatory mechanisms of NO analyzed by using nitronyl nitroxide

2004 - 2005 Analysis on biological formation of a novel modified nucleic acid, 8-nitorguanosine, and its unique signal function

2004 - 2005 On the regulation of survival and death of synoviocytes and chondrocytes by nitric oxide

2004 - 2005 Study for Establishment of a Program Officer System of the Gant-in-Aid for Scientific Research

2003 - 2004 The mechanism of cell- invasion by Vibrio cholerae Non-O1 and several factors which grow worse sepsis

2003 - 2004 Research on a novel mechanism for oxidative stress mediated by NO-induced nucleic acid nitration.

2003 - 2003 感染病態形成におけるフリーラジカル病因論に関する研究

2002 - 2003 従来の概念にはない脂肪細胞の機能解明-スカベンジ機能・貧食能と生体防御-

2002 - 2003 新しいグルタチオン誘導体の発見とそれによる蛋白質機能制御に関する研究

2001 - 2003 Inhibitory effect of human α_2-plasmin inhibitor and it's intensified compound by S-nitrosylation on the activity of arginine-specific cysteine proteinase from Porphyromonas gingivalis.

2002 - 2002 感染病態形成におけるフリーラジカル病因論に関する研究

2002 - 2002 ポリマー結合型エンドスタチンによる癌のターゲティング療法

2001 - 2002 フリーラジカルによるヘリコバクターピロリ遺伝子の変異促進作用に関する研究

2000 - 2002 Research on the role of NO in microbial pathogenesis

2000 - 2002 Study on the mechanism of nitrosothiol formation in biological systems

2000 - 2002 Research on microbial mutation and evolution involving oxidative stress

2000 - 2002 Development of analysis for all biologically relevant derivatives of NO

2001 - 2001 新規水溶性ヘムオキシゲナーゼ阻害剤の合成とその抗腫瘍活性

2000 - 2000 慢性感染に伴うフリーラジカル産生と発がん

2000 - 2000 ポリマー結合酸化酵素による癌のターゲティング化学療法

2000 - 2000 固型腫瘍の発育・進展における一酸化窒素・酸素ラジカルの役割についての研究

1998 - 2000 Study in clinical application of nitric oxide (NO) scavenger for treatment of urinary incontinence

1998 - 2000 A Study on the Role of Protease Produced by Vibrio cholerae non-01 in the Pathogenic Mechanism of Sepsis.

1999 - 1999 Free radical generation in chronic infection and its implication in carcinogenesis

1999 - 1999 フリーラジカルによるマトリックス・メタロプロテアーゼの活性化

1998 - 1999 慢性ウイルス肝炎における肝癌の成因:フリーラジカルと一酸化窒素代謝物による感染性発癌機構

1998 - 1999 フリーラジカルによるウイルス遺伝子変異メカニズムの解明

1997 - 1999 Helicobacter pylori and gastric cancer

1997 - 1999 Molecular Mechanisms of Redox-Regulation in Viral Pathogenesis

1997 - 1999 Matrix metalloproteinase activation in bacterial pathogenesis

1997 - 1999 Therapeutic application of NO scavenger and NO donor for endotoxin shock

1998 - 1998 生体内ラジカル生成による発癌と抗ラジカル物質によるがん抑制

1998 - 1998 感染と炎症におけるメタロプロテアーゼの活性制御

1997 - 1997 メタロプロテアーゼの炎症および組織リモデリングにおける作用メカニズム

1996 - 1996 腫瘍血管透過性亢進メディエーター制御による制癌剤の腫瘍選択的ターゲティングの増強

1996 - 1996 メタロプロテアーゼの炎症および組織リモデリングにおける作用メカニズム

1995 - 1996 Viral Pathogenesis and Regulation Mechanism of Free Radicals in Host Responses : Role of Nitric Oxide

1994 - 1996 Pathogenesis of Bacterial Proteases : Involvement of Bradykinin and Nitric Oxide Synthesis Pathway

1995 - 1995 一酸化窒素合成酵素及びチトクロームP-450還元酵素の誘導による制癌剤感受性増強

1994 - 1994 オキシラジカルによる発癌促進とラジカルスカベンジャーによる抑制-新しい立場から-

1994 - 1994 一酸化窒素合成酵素を標的とした固型癌の診断と治療-とくにNOによる血管透過性亢進作用の制御に基づく-

1994 - 1994 ウイルス感染病態における一酸化窒素(NO)の役割についての研究

1992 - 1993 Involvement of virus infection in the pathogenesis of pulmonary fibrosis

1991 - 1993 Molecular pathogenesis of influenza virus infection : involvement of free radicals and bradykinin