Ikeuchi Takeshi

イケウチタケシ | Ikeuchi Takeshi

Affiliation and department：
Job title：教授
Homepage URL (1)： https://scholar.google.co.jp/citations?user=4VErpEYAAAAJ&hl=ja&oi=ao

Research field (2)： Neurology , Genetics

Research theme for competitive and other funds (34)：

2024 - 2030 タウオパチーにおけるグリア-末梢免疫連関および脳プロテオスタシス変容の理解と制御
2023 - 2026 Next generation biomarker for Alzheimer's disease based on glial pathology
2024 - 2025 認知症治療標的としてのミクログリアによるアストロサイト制御機構に剖検脳から迫る
2022 - 2025 comprehensive search for expanded repeats in neurodegenerative diseaess
2022 - 2025 Loss of homeostatic microglia and cell replacement therapy in primary microgliopathy

2022 - 2025 認知症治療標的としてのミクログリアによるアストロサイト制御機構に剖検脳から迫る

2021 - 2024 タウオパチー病態機序解明を目指すゲノムリソースの網羅的機能解析

2021 - 2024 多系統萎縮症の3つの病態を反映し,早期診断を可能とするバイオマーカーの検討と確立

2020 - 2023 Bassoon proteinopathyの病態解析研究

2019 - 2022 Exploring rare variants associated with Alzheimer disease

2019 - 2022 Impaired essential function of microglia in the pathogenesis of HDLS/ALSP

2019 - 2022 Microglia-astrocyte crosstalk in leukoencephalopathies

2017 - 2019 Comprehensive search for biomarkers predicting dementia using urine metabolomics analysis

2016 - 2019 Microglial involvement in the pathomechanisms of white matter degeneration

2014 - 2019 Establishment of brain protein aging models; human iPS cell model and non-human primate model

2016 - 2018 CSF-1受容体異常によるミクログリア機能破綻と一次性ミクログリア病の病態

2015 - 2018 Validation study on insulin resistance occuring in brain of Alzheimer disease

2015 - 2018 Amino acid profile in plasma of Alzheimer's disease

2015 - 2017 Identification of the pathologically-transited immature cells diagnosed by soluble LR11

2014 - 2017 Amyotrophic Lateral Sclerosis and TDP-43: Elucidation of molecular neuropathology in terms of spread from its beginning

2014 - 2017 Analysis of the mechanism of homeostatic maintenance against Alzheimer's disease and its failure due to diabetes

2014 - 2017 Globular glial tauopathy: investigation of the pathological features

2014 - 2016 一次性ミクログリア病:CSF-1R変異関連HDLSにおけるミクログリアの機能異常

2012 - 2015 Identification of target molecules related the progression of Alzheimer's disease

2012 - 2014 末梢血におけるアルツハイマー病脳関連遺伝子のエピジェネティック・遺伝子発現解析

2011 - 2013 Genetical, morphological, and functional analysis of CHMP2B in a patient of familial FTD

2011 - 2013 Non-biased expression analysis to search for molecules associated with amyloid-beta induced hyperphosphorylation of tau

2009 - 2011 Mutations associated with copy number variation in neurological disorders

2010 - 2010 レビー小体型認知症の診断に有用な髄液中αシヌクレイン簡易ELISA測定キットの開発

2008 - 2010 A role of insulin signal impairment in the pathogenesis of Alzheimer disease

2007 - 2008 Global survey on clinical research supporting and promoting system, aiming Japanese clinical research improvement.

2006 - 2007 Modulation of β-amyloid and phosphorylated tau production by statin

2004 - 2005 A role of transcriptional impairment in pathogenesis for Alzheimer disease

2004 - 2004 特異的γセクレターゼ阻害剤を用いた活性型プレセニリン複合体の調節機構の解析

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Papers (313)：

Eric McDade, Haiyan Liu, Quoc Bui, Jason Hassenstab, Brian Gordon, Tammie Benzinger, Yuanyuan Shen, Jigyasha Timsina, Lihua Wang, Yun Ju Sung, et al. Ubiquitin-Proteasome System in the Different Stages of Dominantly Inherited Alzheimer's Disease. Research square. 2024
Fumihiko Yasuno, Yasuyuki Kimura, Aya Ogata, Hiroshi Ikenuma, Junichiro Abe, Hiroyuki Minami, Takashi Nihashi, Kastunori Yokoi, Saori Hattori, Nobuyoshi Shimoda, et al. Trait-anxiety and glial-related neuroinflammation of the amygdala and its associated regions in Alzheimer's disease: A significant correlation. Brain, behavior, & immunity - health. 2024. 38. 100795-100795
Tomoyasu Matsubara, Kenji Ishii, Yoko Saito, Aya Midori Tokumaru, Akira Arakawa, Manato Hara, Masanori Kurihara, Renpei Sengoku, Kazutomi Kanemaru, Atsushi Iwata, et al. Neurofibrillary tangle-predominant dementia followed by amyloid β pathology: a clinico-radio-pathological case providing insights into current disease-modifying therapeutic strategy. Acta neuropathologica communications. 2024. 12. 1. 98-98
Shin Koide, Shintaro Tsuboguchi, Shingo Koide, Itaru Ninomiya, Taiki Saito, Takanobu Ishiguro, Etsuji Saji, Yo Higuchi, Takeshi Ikeuchi, Makoto Oishi, et al. A patient with neuronal intranuclear inclusion disease developed encephalitis-like symptoms after cerebral angiography. Neurology and Clinical Neuroscience. 2024
Yoshiki Niimi, Shorena Janelidze, Kenichiro Sato, Naoki Tomita, Tadashi Tsukamoto, Takashi Kato, Kenji Yoshiyama, Hisatomo Kowa, Atsushi Iwata, Ryoko Ihara, et al. Combining plasma Aβ and p-tau217 improves detection of brain amyloid in non-demented elderly. Alzheimer's research & therapy. 2024. 16. 1. 115-115

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MISC (389)：

宮下哲典, 大日方藍, 他田真理, 阿部学, 柿田明美, 池内健. BIOLOGY TOPICS APOEレアミスセンスバリアントの探索. BIO Clinica. 2024. 39. 4. 344-345
三橋泉, 石井一弘, 原範和, 池内健, 斉木臣二. 若年で発症した若年で発症したLamin B1関連常染色体優性遺伝性成人発症白質脳症の31歳女性例. 臨床神経学. 2024. 64. 3. 208-208
池内健. 【アルツハイマー病-研究と治療の最前線】バイオマーカーとゲノム疾患修飾薬時代のAPOE遺伝学的検査の臨床的意義. 医学のあゆみ. 2023. 287. 13. 937-941
池内健. 認知症に対する遺伝学的検査の実際メンデル遺伝型認知症とAPOE検査. Dementia Japan. 2023. 37. 4. 597-597
池内健. 認知症疾患修飾薬の実用化を目前に何を議論しておくべきか2023 液性バイオマーカーを用いたアミロイドβ検査の役割. Dementia Japan. 2023. 37. 4. 599-599

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Patents (8)：

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Education (2)：

1996 - 2000 Niigata University Graduate School of Medicine
1984 - 1991 Niigata University Faculty of Medicine School of Medicine

Professional career (1)：

MD, PhD (Niigata University)

Work history (8)：

2020 - 現在 Niigata University Medical and Dental Hospital
2013 - 現在 Niigata University
2011 - 2013 Niigata University Institute for Research Promotion
2004 - 2010 Niigata University Brain Research Institute
2007 - 2008 Ministry of Education,Culture,Sports,Science and Technology

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Awards (2)：

2024/08 - 新潟大学 2020年~2024年学長賞(外部資金獲得奨励)
2023/10 - 新潟日報社新潟日報文化賞(学術部門) 認知症の病態解明と診断治療法の開発

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