Akagi Takumi

Affiliation and department：

Research field (3)： Physiology , Neuroanatomy and physiology , Nervous system function

Research theme for competitive and other funds (11)：

2020 - 2023 網膜コリン作動性ニューロンで発見された新奇なアセチルコリン合成経路の検討
2016 - 2018 Analysis of interacting-partners of Nav1.1 in premature mouse brain
1997 - 1999 The Analysis of Gene Expression of Morphogenetic Factors Implicated Development of Tooth Germ and Odontogenic Tumors
1996 - 1996 歯胚発生過程における骨誘導蛋白質(BMP)-2,4,7遺伝子の局在変化と定量解析
1995 - 1996 Ditribution of bone matrix proteins and PTH recepter mRNA during ectopic bone formation induced by BMP

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Papers (75)：

Atsushi Shimohata, Dilip Rai, Takumi Akagi, Sumiko Usui, Ikuo Ogiwara, Makoto Kaneda. The intracellular C-terminal domain of mGluR6 contains ER retention motifs. Molecular and cellular neurosciences. 2023. 126. 103875-103875
Kei-Ichi Katayama, Naoko Morimura, Katsunori Kobayashi, Danielle Corbett, Takehito Okamoto, Veravej G Ornthanalai, Hayato Matsunaga, Wakako Fujita, Yoshifumi Matsumoto, Takumi Akagi, et al. Slitrk2 deficiency causes hyperactivity with altered vestibular function and serotonergic dysregulation. iScience. 2022. 25. 7. 104604-104604
Dilip Rai, Takumi Akagi, Atsushi Shimohata, Toshiyuki Ishii, Mie Gangi, Takuma Maruyama, Yuko Wada-Kiyama, Ikuo Ogiwara, Makoto Kaneda. Involvement of the C-terminal domain in cell surface localization and G-protein coupling of mGluR6. Journal of Neurochemistry. 2021. 158. 4. 837-848
Yo Shinoda, Tetsushi Sadakata, Takumi Akagi, Yuriko Sakamaki, Tsutomu Hashikawa, Yoshitake Sano, Teiichi Furuichi. Calcium-dependent activator protein for secretion 2 (CADPS2) deficiency causes abnormal synapse development in hippocampal mossy fiber terminals. Neuroscience Letters. 2018. 677. 65-71
Takamitsu Sano, Ayako Kohyama-Koganeya, Masami O. Kinoshita, Tetsuya Tatsukawa, Chika Shimizu, Eriko Oshima, Kazuyuki Yamada, Tung Dinh Le, Takumi Akagi, Koujiro Tohyama, et al. Loss of GPRC5B impairs synapse formation of Purkinje cells with cerebellar nuclear neurons and disrupts cerebellar synaptic plasticity and motor learning. Neuroscience Research. 2018. 136. 33-47

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MISC (23)：

下畑充志, 赤木巧, 荻原郁夫, 金田誠. 代謝型グルタミン酸6型受容体の細胞内輸送に関与するC末端特異的配列の探索. 日本神経化学会大会抄録集(Web). 2022. 65th
赤木巧, 下畑充志, 荻原郁夫, 金田誠. 代謝型グルタミン酸受容体6型の細胞膜表面局在に関するN型糖鎖修飾の役割. 日本神経化学会大会抄録集(Web). 2022. 65th
赤木巧, 石田欣二, 花坂智人, 林秀一郎, 遠山稿二郎. 神経組織を対象とした凍結超薄切片法の安定的手技の確立と組織細胞化学法への応用. バイオイメージング. 2006. 15. 2. 175-175
Ebralum Abdul, A. Shimohata, W. Yu, M. Yamaguchi, M. Murayama, D. Chui, T. Akagi, T. Takeuchi, K. Amano, H. S. Karthik, et al. Tau hyperphosphorylation in Ts1Cje, a partial trisomy 16 mouse model for Down syndrome. NEUROSCIENCE RESEARCH. 2006. 55. S256-S256
前田純宏, 金賢徹, 赤木巧, 宮坂知宏, 原正彦, 端川勉, 猪飼篤, 高島明彦. 顆粒状凝集物を介したタウ線維形成. Dementia Japan. 2004. 18. 2. 147-147

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Lectures and oral presentations (77)：

代謝型グルタミン酸受容体6型のシナプス接着因子Elfn1との結合におけるN型糖鎖修飾の役割
(第92回日本医科大学医学会学術集会 2024)
代謝型グルタミン酸受容体mGluR6の細胞膜表面発現におけるN-結合型グリコシル化の役割
(第92回日本医科大学医学会学術集会 2024)
The impact of N-glycosylation in N-terminal extracellular domain of mGluR6 on the interaction with Elfin1
(2024)
Roles of N-linked glycosylation in mGluR6 cell surface delivery and interaction with ELFN1
(2024)
The intracellular C-terminal domain of mGluR6 works as a signal for ER retention
(2023)

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Education (2)：

2004 - 2008 Iwate Medical University
1981 - 1985 Yamaguchi University Faculty of Science

Professional career (1)：

Ph. D. (Iwate Medical University)

Work history (3)：

2915/04 - 現在 Nippon Medical School
1998/04 - 2015/03 理化学研究所脳科学総合研究センターテクニカルスタッフ
1987/01 - 1998/03 岡山大学歯学部教務員

Association Membership(s) (2)：

日本生理学会 , 日本神経科学学会

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