Rchr
J-GLOBAL ID：201801005968618466
Update date: May. 08, 2024
Komatsu Rie
Komatsu Rie
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Affiliation and department：
St.Marianna University School of Medicine
About St.Marianna University School of Medicine
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Research field (1)：
Orthopedics
Research theme for competitive and other funds (4)：
2021 - 2024 滑膜線維芽細胞において炎症性サイトカインで誘導されるCDK6の作用点の解明
2013 - 2017 Potential of SPACIA1 as a druggable target of rheumatoid arthritis
2012 - 2014 Study on the molecular mechanism controlled by SPACIA1, which associated with synoviocyte proliferation.
2010 - 2012 Study of novel factor, SPACIA1 which is expressed in synovial tissue in rheumatoid arthritis.
Papers (10)：
藤井亮爾, 小松梨恵, 仁木久照, 遊道和雄. 関節リウマチ由来滑膜線維芽細胞において炎症性サイトカインで誘導される細胞周期因子cyclin-dependent kinase 6. 聖マリアンナ医科大学雑誌. 2019. 46. 4. 239-247
Fujii R, Komatsu R, Sato T, Seki I, Konomi K, Aono H, Niki H, Yudoh K, Nishioka K, Nakajima T. SPACIA1/SAAL1 Deletion Results in a Moderate Delay in Collagen-Induced Arthritis Activity, along with mRNA Decay of
Cyclin-dependent Kinase 6
Gene. International journal of molecular sciences. 2018. 19. 12
Ryoji Fujii, Iwao Seki, Rie Komatsu, Tomomi Kohara, Miwa Takai, Tomoo Sato, Koji Konomi, Hiroyuki Aono, Kazuo Yudoh, Kusuki Nishioka, et al. SPACIA1/SAAL1-Deficient Mice Show Reduced Disease Progression in Collagen-Induced Arthritis. ARTHRITIS & RHEUMATOLOGY. 2015. 67
Koki Yamamura, Masao Doi, Hida Hayashi, Takumi Ota, Iori Murai, Yunhong Hotta, Rie Komatsu, Hitoshi Okamura. Immunolocalization of murine type VI 3 beta-hydroxysteroid dehydrogenase in the adrenal gland, testis, skin, and placenta. MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2014. 382. 1. 131-138
Komatsu Rie, Fujii Ryoji, Sato Tomoo, Yamano Yoshihisa, Yudoh Kazuo, Beppu Moroe, Nishioka Kusuki, Nakajima Toshihiro. CDK6 Transcripts Expression Control By The Synoviocyte Proliferation Gene, SPACIA1. ARTHRITIS AND RHEUMATISM. 2013. 65. S1033-S1034
ｍore...
MISC (1)：
小松梨恵, 仁木久照, 遊道和雄, 藤井亮爾. SPACIA1/SAAL1の遺伝子欠損. 臨床雑誌 整形外科. 2021. 72. 1
Lectures and oral presentations (6)：
TNFα誘導性滑膜線維芽細胞における抗リウマチ薬によるRBリン酸化制御の違い
(第68回日本リウマチ学会 2024)
関節リウマチ滑膜細胞において TNFαは cdk4 ではなく cdk6 遺伝子を発現誘導する
(第34回日本整形外科学会基礎学術集会 2019)
SPACIA1/SAAL1の遺伝子欠損はCDK6のmRNA分解に関与し、CIAモデルにおける関節炎の進展を軽減する
(第34回日本整形外科学会基礎学術集会 2019)
マウスCIA誘導関節炎の重症度の違いにおけるSPACIA1/SAAL1遺伝子欠損の影響
(第63回日本リウマチ学会 2019)
Effect of SPACIA1/SAAL1 knockdown on TNF-α-induced CDK6 expression in vitro.
(The 62nd Annual General Assembly and Scientific Meeting of the Japan College of Rheumatology 2018)
ｍore...
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