Rchr

J-GLOBAL ID：201801006655070261 Update date: Jun. 18, 2024

Imoto Issei

イモトイッセイ | Imoto Issei

Affiliation and department：
Homepage URL (1)： https://www.pref.aichi.jp/cancer-center/ri/01bumon/10bunshi_idengaku/index.html

Research field (2)： Systems genomics , Tumor biology

Research theme for competitive and other funds (45)：

2022 - 2028 Platform of Supporting Cohort Study and Biospecimen Analysis
2023 - 2026 Evaluation for the scope of genetic counseling by non-medically qualified professionals
2022 - 2025 食物繊維摂取とがん罹患リスクの関連:遺伝的リスクを考慮した大規模コホート研究
2019 - 2022 定量ctDNA解析の切除可能境界膵癌に対する術前治療の効果と手術適応判定への応用
2019 - 2022 Quantitative CT assessment of long-term progression of emphysema for heavy smokers and identification of progression-related gene

2018 - 2021 Development of minimally invasive diagnostic methods and epigenomic therapies focusing on founder epi-drivers in lung adenocarcinoma.

2016 - 2021 Platform of Supporting Cohort Study and Biospecimen Analysis

2016 - 2019 Identification and clinical use of susceptibility gene of central serous chorioretinopathy

2014 - 2019 Cancer Diagnosis and Prognosis Assistance Based on Multidisciplinary Computational Anatomy

2016 - 2018 Characterization of the esophageal carcinogenesis-promoting molecular switch existing inside the isoform of RNA-binding protein

2015 - 2018 Physiological role of dietary nitrite

2015 - 2018 Formulation of decision-making on persons with higher brain dysfunction

2015 - 2018 Genetic testing for HBOC-related gene mutation provides important risk information for ovarian cancer patients in Japan

2014 - 2017 Epigenetic regulation of stress vulnelability

2014 - 2017 Optimization of therapeutic strategy for esophageal squamous cell carcinoma based on modeling of intratumoral heterogeneity using omics data and genome editing

2014 - 2017 Research strategy for identification of the pathogenesis of the common structural abnormalies in craniomaxillofacial region

2014 - 2017 Analysis of TFG gene and development of treatment for motor neuron diseases

2014 - 2017 Approach for identification of novel causative genes in male infertility

2013 - 2016 Elucidation of environmental factors associated with dental visits among hemodialysis patients

2013 - 2015 Imaging genetics analysis in autism spectrum disorder

2012 - 2015 Experimental analysis of the factors which predict the prognosis and the efficacy of preoperative systemic chemotherapy with taxane for esophageal cancer

2013 - 2014 Molecular genetic analysis of atherosclerosis and atrial thrombosis rat model spontaneously induced by hypoactivity

2012 - 2014 肝発癌分子機構におけるがん幹細胞関連miRNA発現の関与

2011 - 2014 Construction of predictive algorithm for therapeutic effect and exploration of molecular targets in esophageal cancer by the next-generation integrated genome analysis

2012 - 2012 Construction of systematic tools forgenome analysesto determinegenes responsible for various disease model in rats

2010 - 2012 Development of diagnostic tools for personalized cancer medicine by genomic and epigenomic analyses

2011 - 2011 Rapid screening of gene(s) related to the phenotype of model rats with high levels of voluntarily wheel running activity

2008 - 2010 Identification of target genes for esophageal cancers through integrative analysis of genomic alterations and oncogene addiction

2005 - 2009 Integrative genomics and epigenomics for personalized cancer medicine

2005 - 2009 Development and application of high-density genomic microarray system as a tool for human genome structural variation

2006 - 2008 Exploration of diagnostic and therapeutic target molecules through integration of 'omics' data based on array technology

2006 - 2007 Exploration of diagnostic and therapeutic targets through array-based analyses for genomic and epigenomic alterations in esophageal squamous-cell carcinoma

2005 - 2006 Development of array based comparative genomic hybridization (CGH) as a diagnostic tool for cryptic chromosome aberrations in congenital disorders

2004 - 2005 Identification of molecular target for diagnosis and therapy of esophageal squamous-cell carcinoma based on microarray technology.

2003 - 2005 Exploration of molecular targets for diagnosis and therapy of oral cancer through array-CGH based analysis of cancer genome.

2004 - 2004 ヒトゲノム構造解析ツールとしての高密度ゲノムDNAマイクロアレイの開発と応用

2003 - 2004 Establishment of array-based CGH technology and its use for-diagnosis of genetic diseases in clinical setting

2000 - 2004 がんの新規ゲノム異常の探索と多項目遺伝情報によるがんの個性診断法の開発

2003 - 2003 ヒトゲノム構造解析ツールとしての高密度genomic DNAマイクロアレイの開発

2002 - 2003 Molecular Mechanism of cIAP1 in Malignant Progression of Human Cancer

2002 - 2002 ヒトゲノム構造解析ツールとしての高密度genomic DNAマイクロアレイの開発

2001 - 2002 Exploring novel cancer-related genes within novel amplifications detected by CGH in gastrointestinal tumors

2001 - 2001 ヒトゲノム構造解析ツールとしての高密度genomic DNAマイクロアレイの開発

2000 - 2000 ヒトゲノム構造解析ツールとしての高密度genomic DNAマイクロアレイの開発

1995 - 1996 Role of extracellular matrix, cytokines and gut hormones on pancreatic fibrosis in arginine-induced pancreatitis.

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Papers (341)：

Akiko Hanyuda, Atsushi Goto, Ryoko Katagiri, Yuriko N Koyanagi, Masahiro Nakatochi, Yoichi Sutoh, Shiori Nakano, Isao Oze, Hidemi Ito, Taiki Yamaji, et al. Investigating the association between glycaemic traits and colorectal cancer in the Japanese population using Mendelian randomisation. Scientific reports. 2023. 13. 1. 7052-7052
Yoshiaki Usui, Yukari Taniyama, Mikiko Endo, Yuriko N Koyanagi, Yumiko Kasugai, Isao Oze, Hidemi Ito, Issei Imoto, Tsutomu Tanaka, Masahiro Tajika, et al. Helicobacter pylori, Homologous-Recombination Genes, and Gastric Cancer. The New England journal of medicine. 2023. 388. 13. 1181-1190
Akiko Hanyuda, Atsushi Goto, Masahiro Nakatochi, Yoichi Sutoh, Akira Narita, Shiori Nakano, Ryoko Katagiri, Kenji Wakai, Naoyuki Takashima, Teruhide Koyama, et al. Association Between Glycemic Traits and Primary Open-Angle Glaucoma: A Mendelian Randomization Study in the Japanese Population. American journal of ophthalmology. 2023. 245. 193-201
Yuriko N Koyanagi, Isao Oze, Yumiko Kasugai, Yukino Kawakatsu, Yukari Taniyama, Kazuo Hara, Yasuhiro Shimizu, Issei Imoto, Hidemi Ito, Keitaro Matsuo. New insights into the genetic contribution of ALDH2 rs671 in pancreatic carcinogenesis: Evaluation by mediation analysis. Cancer science. 2022. 113. 4. 1441-1450
Yumiko Kasugai, Tomohiro Kohmoto, Yukari Taniyama, Yuriko N Koyanagi, Yoshiaki Usui, Madoka Iwase, Isao Oze, Rui Yamaguchi, Hidemi Ito, Issei Imoto, et al. Association between germline pathogenic variants and breast cancer risk in Japanese women: The HERPACC study. Cancer science. 2022. 113. 4. 1451-1462

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MISC (169)：

Yosuke Matsushita, Masato Komatsu, Kazuma Kiyotani, Takeshi Niinuma, Hiromu Suzuki, Tetsuro Yoshimaru, Atsushi Tajima, Issei Imoto, Junko Honda, Yoichi Furukawa, et al. Epigenetic alteration of SALL3 contributes to chemoresistance in triple-negative breast cancer. CANCER SCIENCE. 2022. 113. 752-752
Yosuke Matsushita, Masato Komatsu, Kazuma Kiyotani, Tetsuro Yoshimaru, Takeshi Niinuma, Hiromu Suzuki, Junko Honda, Issei Imoto, Akira Tangoku, Yasuo Miyoshi, et al. Recurrent silencing of SALL3 is involved in progression and chemoresistance of triple negative breast cancers. CANCER SCIENCE. 2021. 112. 503-503
土屋実央, 山田崇弘, 赤石理奈, 井本逸勢, 梅村啓史, 清水健司, 浜之上はるか, 平沢晃, 吉田晶子, 吉橋博史, et al. The present status and attitudes for reporting secondary findings in genomic analysis using a next-generation sequencer: A nation-wide questionnaire survey of clinical genetic professionals in Japan. 日本遺伝カウンセリング学会誌. 2020. 41. 2
赤羽智子, 赤羽智子, 西原広史, 平沢晃, 平沢晃, 平沢晃, 井本逸勢, 井本逸勢, 増田健太, 坂本一平, et al. BRCA1VUS保持卵巣癌例おけるバリアントの病的意義に関する検討. 日本遺伝性腫瘍学会学術集会プログラム・抄録集. 2020. 26th
Yosuke Matsushita, Masato Komatsu, Kazuma Kiyotani, Tetsuro Yoshimaru, Takeshi Niinuma, Hiromu Suzuki, Junko Honda, Issei Imoto, Akira Tangoku, Yasuo Miyoshi, et al. Downregulation of SALL3 by recurrent genetic and epigenetic alterations is involved in triple negative breast cancers. CANCER SCIENCE. 2018. 109. 963-963

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Patents (1)：

核酸マイクロアレイの異常スポットを検出する方法

Education (1)：

- 1987 Kyoto Prefectural University of Medicine

Professional career (1)：

医学博士 (京都府立医科大学)

Work history (3)：

2021/04 - 現在 Aichi Cancer Center, Research Institute Director
2018/04 - 2021/03 Aichi Cancer Center Hospital Risk assessment center Division head
2010/05 - 2018/03 Tokushima University

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