Jun Mukai

ムカイジュン | Jun Mukai

Affiliation and department：
Job title：教授
Homepage URL (1)： https://rdcpm.tsukuba.ac.jp/en/faculty/

Research field (4)： Psychiatry , Psychiatry , Psychiatry , Neuroscience - general

Research keywords (23)： Precision Psychiatry , 精密精神医学 , schizophrenia , 22.q11.2 microdeletion syndrome , SETD1A , working memory , histon modification , epigenetics , Precision Medicine , NGS , neurodevelopmental disease , プレシジョンメディシン , 個別化医療 , psychiatric disease , precision medicine , Alzheimer's disease , chromatin remodeling , dementia , microRNA , DGCR8 , enhancer , neuron , autism

Research theme for competitive and other funds (6)：

2022 - 2025 Elucidation of pathological neural circuit formation mechanism for early therapeutic intervention of cognitive dysfunction in psychiatric disease.
2019 - 2022 Decifering the role of histone methyltransferase Setd1a in schizophrenia
1995 - 1996 Novel all signoling in vascular smooth muscle
1995 - 1995 心筋細胞の分化機構に関する分子生物学的研究
1994 - 1995 Molecular Pharmacology of Leucocyte Activation

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Papers (32)：

向井淳, 福田茉由. 統合失調症の未来 -研究と治療「統合失調症のエピゲノムを標的とした治療薬」. 医学のあゆみ. 2023. 286. 6
福田茉由, 向井淳. 統合失調症の認知機能障害を改善するエピゲノム治療薬の開発. 精神科. 2021. 38. 2
Jordan P. Hamm, Yuriy Shymkiv, Jun Mukai, Joseph A Gogos, Rafael Yuste. Aberrant cortical ensembles and schizophrenia-like sensory phenotypes in setd1a mice. Biological Psychiatry. 2020. 88. 3. 215-223
Jun Mukai, Enrico Cannavò, Gregg W Crabtree, Ziyi Sun, Anastasia Diamantopoulou, Pratibha Thakur, Chia-Yuan Chang, Yifei Cai, Stavros Lomvardas, Atsushi Takata, et al. Recapitulation and Reversal of Schizophrenia-Related Phenotypes in Setd1a-Deficient Mice. Neuron. 2019. 104. 3. 471-487
Choi SJ, Mukai J, Kvajo M, Xu B, Diamantopoulou A, Pitychoutis PM, Gou B, Gogos JA, Zhang H. A Schizophrenia-Related Deletion Leads to KCNQ2-Dependent Abnormal Dopaminergic Modulation of Prefrontal Cortical Interneuron Activity. Cerebral cortex (New York, N.Y. : 1991). 2018. 28. 6. 2175-2191

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Education (2)：

1990 - 1994 Mie University
1982 - 1988 Mie University School of Medicine

Professional career (1)：

MD, PhD. (Mie University)

Work history (6)：

2022/01 - 現在 University of Tsukuba Research and Development Center for Precision Medicine, Laboratory of Precision Psychiatry and Neuroscience Professor
2018/07 - 2021/12 University of Tsukuba Research and Development Center for Precision Medicine Pofessor
2017/12 - 2018/06 Mortimer B. Zuckerman Mind Brain and Behavior Institute
2002/12 - 2017/11 Columbia University Physiology Research Associate
1998/05 - 2002/11 Columbia University Pathology Post Doctoral Fellow

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Awards (2)：

2008/07 - NARSAD (National Alliance for Research on Schizophrenia and Depression) Young investigator award Assembly of neural circuits in a reliable genetic mouse model of schizophrenia
2005/07 - NARSAD (National Alliance for Research on Schizophrenia and Depression) Young investigator award Impaired palmitate modification of neuronal proteins and the psychiatric phenotypes associated with 22q11 microdeletions

Association Membership(s) (3)：

THE JAPAN NEUROSCIENCE SOCIETY , THE JAPANESE PHARMACOLOGICAL SOCIETY , THE JAPANESE BIOCHEMICAL SOCIETY

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