Research field (1)：
Pharmaceuticals - chemistry and drug development
Research keywords (3)：
有機化学
, ラジカル反応
, 核酸化学
Research theme for competitive and other funds (4)：
2022 - 2025 1,5-水素原子移動反応を利用したヌクレオシドの位置選択的エピメリ化法
2019 - 2021 Development of functional oligonucleotides by utilizing the reactivity of 5-trifluoromethyl pyrimidine bases
2018 - 2019 糖部4ʹ-炭素ラジカルを活用した4'-置換ヌクレオシド類の開発
2017 - 2019 Practical synthesis of oligonucleotides containing epigenetic cytosines
Papers (35)：
Misa Shoji, Yasufumi Fuchi, Yuta Ito, Yoshiyuki Hari. Synthesis and characterization of oligonucleotides containing 2′-O,4′-C-methyleneoxy-bridged 5-methyluridine with an unsubstituted bridge. Tetrahedron. 2024. 163
Yuta Ito, Hisato Tanaka, Ayana Murakami, Yasufumi Fuchi, Yoshiyuki Hari. Synthesis of fluorescent 5-heteroarylpyrimidine-containing oligonucleotides via post-synthetic trifluoromethyl conversion. Organic and Biomolecular Chemistry. 2024. 22. 17. 3510-3517
Yasufumi Fuchi, Miho Kawaguchi, Yuta Ito, Yoshiyuki Hari. Synthesis and Properties of 2′-Deoxyadenosine Mimics Bearing a Thieno[3,2- d ]pyrimidine Ring. Synlett. 2023. 35. 6. 716-720
Yuta Ito, Chisa Takemori, Yoshiyuki Hari. Chemical Conversion of 5-Fluoromethyl- and 5-Difluoromethyl-Uracil Bases in Oligonucleotides Using Postsynthetic Modification Strategy. Current Protocols. 2023. 3. 7
Yasufumi Fuchi, Kouki Watanabe, Misa Shoji, Yuta Ito, Yoshiyuki Hari. Synthesis of purine derivatives of Me-TaNA and properties of Me-TaNA-modified oligonucleotides. Organic and Biomolecular Chemistry. 2023. 21. 25. 5203-5213
Yuta Ito. Synthesis of Modified Nucleosides Using 4′-Carbon Radicals. YAKUGAKU ZASSHI. 2024. 144. 9. 877-886
Yuta Ito, Yoshiyuki Hari. Synthesis of Nucleobase-Modified Oligonucleotides by Post-Synthetic Modification in Solution. Chemical record. 2022. 22. 5. e202100325
