Research field (3):
Nutrition and health science
, Applied microbiology
, Food sciences
Research theme for competitive and other funds (10):
2023 - 2028 Gut microbiomics
2023 - 2027 New strategy for preventing colorectal cancer by targeting polyamines, which are thought to be carcinogens
2023 - 2026 Establishment of technology for intestinal polyamine production by combining non-digestible peptides and bacteria from fermented foods.
2022 - 2025 The gut-heart axis as a therapeutic target
2022 - 2024 パーキンソン病発症起点としてのmicrobiome-gut連関機構の解明
2020 - 2023 Optimization of polyamine levels in the intestinal tract by controlling gut microbiota using lactic acid bacteria from traditional fermented foods
2020 - 2023 Strategy of dementia prevention using functional food based on gut microbiota-gut-brain axis
2021 - 2022 腸内細菌叢-ホルモン-脳システムをもとにした食品による認知症予防戦略
2019 - 2021 ノトバイオート蝿を用いた健康寿命の腸内細菌による延伸効果の解析
2009 - 2012 健康寿命伸長のための腸内ポリアミン濃度コントロール食品の開発
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Papers (62):
Saki Tsuno, Kazuki Harada, Mina Horikoshi, Marie Mita, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi. Mitochondrial ATP concentration decreases immediately after glucose administration to glucose-deprived hepatocytes. FEBS open bio. 2024. 14. 1. 79-95
Mina Horikoshi, Kazuki Harada, Saki Tsuno, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Shin Terada, Takashi Tsuboi. Distinct lactate metabolism between hepatocytes and myotubes revealed by live cell imaging with genetically encoded indicators. Biochemical and biophysical research communications. 2023. 694. 149416-149416
Potential of gut microbiome-derived polyamine as a source of polyamines
(International Conference on the Biological Roles of Polyamines 2024, 7th Yamada Symposium 2024)
2021/03 - Japan Society for Bioscience, Biotechnology, and Agrochemistry Hot Topics Award at Annual Meeting of Japan Society for Bioscience, Biotechnology, and Agrochemistry Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon
2020/03 - Japan Society for Bioscience, Biotechnology, and Agrochemistry JSBBA Aword for Achievement in Technological Research Development of functional food that induces microbial polyamine production in the gut
2018/09 - Royal Society of Chemistry Tokyo International Conference 2018. Best Poster Award. Simultaneous analysis of 42 chiral amino acids produced by intestinal microbiota in biological samples by high-throughput LC-MS/MS
日本ポリアミン学会
, Japanese Society of Anti-aging Medicine
, JAPAN SOCIETY FOR LACTIC ACID BACTERIA
, JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY