Research theme for competitive and other funds (15):
2023 - 2028 Development of single-molecule peptide sequencing method
2022 - 2026 血液中の自己抗体を用いた難治性内分泌腫瘍の新規悪性度判定法開発
2022 - 2024 高速分子動画でTRPチャネルの温度センサー部位を見極める
2018 - 2023 予後不良の甲状腺癌を識別する血清中癌特異的自己抗体検出法の開発
2020 - 2022 高速分子動画撮影によるTRPチャネルの熱刺激応答機構の解明
2018 - 2021 Structural basis for multimodal sensation in TRP channels
2016 - 2019 A New Diagnostic System Detecting Serum Autoantibodies to Papillary Thyroid Carcinoma
2013 - 2017 A New Serological Screening Method Developed from SEREX to Differentiate High-risk Thyroid Carcinoma
2013 - 2016 Structural biology of thermosensation in human
2012 - 2015 Structure determination of histamine H1 receptor
2012 - 2013 エキソペプチダーゼを活用したタンパク質結晶化促進技術の開発
2011 - 2012 Structural study on the generation mechanism of nitrous oxide by integral membrane protein nitric oxide reductase
2007 - 2009 Crystallographic Studies on the Short-lived Respiratory Enzyme-Substrate Complex
2004 - 2007 Bio-conversion of Substances and Information by Metal-containing Proteins and Enzymes
2001 - 2002 膜融合を利用した膜蛋白質の結晶化及び高分解能X線結晶構造解析
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Papers (56):
Alexander M Wolff, Eriko Nango, Iris D Young, Aaron S Brewster, Minoru Kubo, Takashi Nomura, Michihiro Sugahara, Shigeki Owada, Benjamin A Barad, Kazutaka Ito, et al. Mapping protein dynamics at high spatial resolution with temperature-jump X-ray crystallography. Nature chemistry. 2023
Tesshin Uegaki, Taisei Takei, Shuhei Yamaguchi, Keisuke Fujiyama, Yusuke Sato, Tomoya Hino, Shingo Nagano. Anammox Bacterial S-Adenosyl-l-Methionine Dependent Methyltransferase Crystal Structure and Its Interaction with Acyl Carrier Proteins. International journal of molecular sciences. 2023. 24. 1
Ryoji Suno, Yukihiko Sugita, Kazushi Morimoto, Hiroko Takazaki, Hirokazu Tsujimoto, Mika Hirose, Chiyo Suno-Ikeda, Norimichi Nomura, Tomoya Hino, Asuka Inoue, et al. Structural insights into the G protein selectivity revealed by the human EP3-Gi signaling complex. Cell Reports. 2022. 40. 11. 111323-111323
Takaki Okamoto, Kazuya Yamanaka, Yoshimitsu Hamano, Shingo Nagano, Tomoya Hino. Crystal structure of the adenylation domain from an ε-poly-l-lysine synthetase provides molecular mechanism for substrate specificity. Biochemical and biophysical research communications. 2022. 596. 43-48
Ryuhei Nagata, Hironori Suemune, Masaya Kobayashi, Tetsuro Shinada, Kazuo Shin-ya, Makoto Nishiyama, Tomoya Hino, Yusuke Sato, Tomohisa Kuzuyama, Shingo Nagano. Structural Basis for the Prenylation Reaction of Carbazole-Containing Natural Products Catalyzed by Squalene Synthase-like Enzymes. Angewandte Chemie International Edition. 2022. 61. 20. e202117430