Uchida Satoshi

ウチダサトシ | Uchida Satoshi

Affiliation and department：
Job title： Professor
Homepage URL (2)： https://www.tmd.ac.jp/mri/anme/index.html , https://www.tmd.ac.jp/mri/anme/en/index.html

Research field (1)： Biomedical engineering

Research keywords (5)： Drug delivery system , Polyplex micelle , Vaccine , Messenger RNA therapeutics , Gene therapy

Research theme for competitive and other funds (5)：

2021 - 2025 Development and therapeutic application of short mRNA therapeutics based on mRNA engineering
2021 - 2023 In situ PEGylation of extracellular DNA using functional peptides for anti-inflammatory therapy
2020 - 2023 Cancer immunotherapy by in vivo generation of CAR T cells based on targeted mRNA delivery
2018 - 2020 Development of mRNA drug with RNA type aptamer conferring cell type specific translation activation function
2013 - 2017 Development of Polymeric Micelles for Brain-Targeted Delivery of Nucleic Acid Drugs to Treat Intractable Neurological Diseases

Papers (84)：

Yuki Mochida, Satoshi Uchida. mRNA vaccine designs for optimal adjuvanticity and delivery. RNA Biology. 2024
Saed Abbasi, Miki Matsui-Masai, Fumihiko Yasui, Akimasa Hayashi, Theofilus A. Tockary, Yuki Mochida, Shiro Akinaga, Michinori Kohara, Kazunori Kataoka, Satoshi Uchida. Carrier-free mRNA vaccine induces robust immunity against SARS-CoV-2 in mice and non-human primates without systemic reactogenicity. Molecular Therapy. 2024
Miki Suzuki, Yuki Mochida, Mao Hori, Akimasa Hayashi, Kazuko Toh, Theofilus A. Tockary, Xueying Liu, Victor Marx, Hidetomo Yokoo, Kanjiro Miyata, et al. Poly(ethylene Glycol) (PEG)-OligoRNA Hybridization to mRNA Enables Fine-Tuned Polyplex PEGylation for Spleen-Targeted mRNA Delivery. Small Science. 2024
Lucas Mixich, Eger Boonstra, Keita Masuda, Shang-Wei Li, Yuki Nakashima, Fanlu Meng, Momoko Sakata, Tatsuro Goda, Satoshi Uchida, Horacio Cabral. Ionizable Polymeric Micelles with Phenylalanine Moieties Enhance Intracellular Delivery of Self-Replicating RNA for Long-Lasting Protein Expression In Vivo. Biomacromolecules. 2024
Jongmin Yum, Fadlina Aulia, Keisuke Kamiya, Mao Hori, Nan Qiao, Beob Soo Kim, Mitsuru Naito, Satomi Ogura, Tetsuya Nagata, Takanori Yokota, et al. Hydrophobicity Tuning of Cationic Polyaspartamide Derivatives for Enhanced Antisense Oligonucleotide Delivery. Bioconjugate chemistry. 2024

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MISC (50)：

BOONSTRA Eger, MIXICH Lucas, YANG Wenqian, CHEN Pengwen, 増田圭汰, 内田智士, CABRAL Horacio. 高分子ベクターを用いたレプリコンRNAデリバリーを基盤としたがん遺伝子ワクチンの開発. 日本DDS学会学術集会プログラム予稿集. 2022. 38th
Satoshi Uchida, Naoto Yoshinaga, Kyoko Koji, Horacio Cabral. Assembling Several mRNA Strands for Facilitating mRNA Delivery with and without Using Carriers. MOLECULAR THERAPY. 2021. 29. 4. 55-55
Takuya Miyazaki, Satoshi Uchida, Yuji Miyahara, Akira Matsumoto, Horacio Cabral. Development of Flexible Polycation-Based mRNA Delivery Systems for In Vivo Applications. Materials Proceedings. 2020. 4. 1. 5-5
Horacio Cabral, Takuya Miyazaki, Satoshi Uchida. Development of polymeric micelles for in vivo mRNA delivery through stable complexation with flexible block catiomers. Proceedings of 2nd International Online-Conference on Nanomaterials. 2020
位高啓史, 位高啓史, LIN Chin-Yu, 内田智士, 内田智士, 小牧裕司, 松本征仁, 片岡一則. mRNA医薬による治療用転写因子の生体内送達と組織再生治療. 日本再生医療学会総会(Web). 2020. 19th

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Patents (24)：

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Books (1)：

Drug and gene delivery in the lungs, Nanoparticles in the lung: environmental exposure and drug delivery
CRC press, Taylor & Francis Group 2015

Education (4)：

Work history (10)：

2023/01 - 現在 Kyoto Prefectural University of Medicine Graduate School of Medical Science
2023/01 - 現在 Tokyo Medical and Dental University Medical Research Institute Professor
2022/04 - 現在 Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine (iCONM)
2020/09 - 2022/12 Kyoto Prefectural University of Medicine Graduate School of Medical Science Associate Professor
2020/09 - 2022/03 Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine (iCONM) Deputy Principal Research Scientist

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Awards (8)：

2020/11 - Young Investigator Award, the Nucleic Acids Therapeutics Society of Japan
2020/11 - 8th International mRNA Health Conference 1st Abstract Prize
2018/06 - The Japan Society of Drug Delivery System 10th Young Scientist Award
2016/09 - Japanese and Korean Biomaterials Societies Young Scientist Exchange Program Award (2016)
2014/09 - Young Investigator Award at the Antisense, Gene, Delivery Symposium 2014

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Association Membership(s) (4)：

THE NUCLEIC ACIDS THERAPEUTICS SOCIETY OF JAPAN , THE JAPANESE SOCIETY FOR BIOMATERIALS , THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM , ナノ・メディカル学会

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