AKAMINE Takahiro

Affiliation and department：

Research field (1)： Pharmacology

Research keywords (3)：体内時計 , 時間薬理学 , 時間治療

Research theme for competitive and other funds (6)：

2022 - 2024 ARDS治療を指向したROCKの新規血管透過性制御機構の解明
2019 - 2023 Wnt/β-catenin経路を標的とした増殖硝子体網膜症の治療法の開発
2020 - 2022 血管透過性調節機構に基づくARDS治療の基盤構築
2019 - 2022 Gastric carcinogenesis caused by Helicoobacter pylori-induced inflammation
2019 - 2022 Investigation of skin homeostasis based on the regulation of actin cytoskeleton

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Papers (11)：

Yuya Tsurudome, Takahiro Akamine, Michiko Horiguchi, Yukiyo Wada, Akio Fujimura, Kentaro Ushijima. Potential mechanism of hepatic lipid accumulation during a long-term rest phase restricted feeding in mice. Chronobiology international. 2022. 39. 8. 1-12
Naoki Kusunose, Akito Tsuruta, Kengo Hamamura, Yuya Tsurudome, Yuya Yoshida, Takahiro Akamine, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo. Circadian expression of Glycoprotein 2 (Gp2) gene is controlled by a molecular clock in mouse Peyer's patches. Genes to cells : devoted to molecular & cellular mechanisms. 2020. 25. 4. 270-278
Yuki Kanado, Yuya Tsurudome, Yuji Omata, Sai Yasukochi, Naoki Kusunose, Takahiro Akamine, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo. Estradiol regulation of P-glycoprotein expression in mouse kidney and human tubular epithelial cells, implication for renal clearance of drugs. Biochemical and biophysical research communications. 2019. 519. 3. 613-619
Kusunose N, Akamine T, Kobayashi Y, Yoshida S, Kimoto K, Yasukochi S, Matsunaga N, Koyanagi S, Ohdo S, Kubota T. Contribution of the clock gene DEC2 to VEGF mRNA upregulation by modulation of HIF1α protein levels in hypoxic MIO-M1 cells, a human cell line of retinal glial (Müller) cells. Japanese journal of ophthalmology. 2018. 62. 6. 677-685
Katamune C, Koyanagi S, Hashikawa KI, Kusunose N, Akamine T, Matsunaga N, Ohdo S. Mutation of the gene encoding the circadian clock component PERIOD2 in oncogenic cells confers chemoresistance by up-regulating the Aldh3a1 gene. The Journal of biological chemistry. 2018. 294. 2. 547-558

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MISC (9)：

森田朱莉, 鶴留優也, 赤嶺孝祐, 金堂有起, 嶋岡雄大, 楠瀬直喜, 松永直哉, 小柳悟, 大戸茂弘. 足場タンパク質の発現リズムに基づいた脂肪酸取り込みトランスポーターの機能シミュレーションモデルの構築. 日本薬学会九州支部大会講演要旨集. 2017. 34th
Satoru Koyanagi, Takahiro Akamine, Erika Wada, Naoki Kusunose, Marie Taniguchi, Naoya Matsunaga, Shigehiro Ohdo. CIRCADIAN OSCILLATION IN THE INTESTINAL EXPRESSION OF OCTN1/SLC22A4 UNDERLIES THE DOSING TIME-DEPENDENT CHANGES IN THE ABSORPTION OF PREGABALIN AND ITS ANALGESIC EFFECTS ON DIABETIC NEUROPATHY. DRUG METABOLISM AND PHARMACOKINETICS. 2017. 32. 1. S89-S89
木藤弘子, 石田保美, 赤嶺孝祐, 橋本華, 國見美紀, 諸岡由美子, 廣渡隆, 小柳悟, 大戸茂弘, 神村英利. パリペリドン錠一包化後の放出特性と患者の評価. 薬理と治療. 2016. 44. 1. 65-69
赤嶺孝祐, 楠瀬直喜, 増井裕亮, 和田惠里香, 松永直哉, 小柳悟, 大戸茂弘. 糖尿病性の末梢神経障害性疼痛に対するプレガバリンの時間薬物動態学的研究. 日本薬学会年会要旨集. 2014. 134年会. 4. 56-56
Akamine Takahiro, Wakamatsu Natsumi, Yokoyama Eri, Matsunaga Naoya, Koyanagi Satoru, Ohdo Shigehiro. Solubility and Dissolution Properties of Generic Versions of Gemcitabine Hydrochloride Preparation for Injection. Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences). 2013. 39. 4. 220-224

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Professional career (1)：

臨床薬学 (九州大学大学院薬学府)

Work history (1)：

2013/04 - 2017/03 Kyushu University

Awards (1)：

2014 - 第3回日本くすりと糖尿病学会学術集会優秀ポスター賞

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