Shitara Akiko

シタラアキコ | Shitara Akiko

Affiliation and department：
Job title：准教授
Homepage URL (1)： http://scw.asahi-u.ac.jp/~pharmaco/

Research field (2)： Surgical dentistry , Oral medicine

Research keywords (13)： Rho , Actin cytoskeleton , molecular target drug , radiation injuries , Xerostomia , Radiation , Cell polarity , Cdc42 , membrane trafficking , Exocytosis , Live imaging , in vivo imaging , Salivary gland

Research theme for competitive and other funds (8)：

2022 - 2025 唾液腺原基のブランチング形成初期過程におけるオートファジーの関わり
2021 - 2024 唾液腺細胞のCdc42依存性恒常性維持機構に着目した、新規放射線防御機構の解明
2019 - 2022 耳下腺および膵アミラーゼの開口分泌に寄与する脂質ラフト上のMARCKSの役割
2019 - 2022 胎生唾液腺原基の培養評価系を用いた器官の凍結保存技術の開発
2017 - 2020 Mechanisms of Cdc42-dependent salivary acinar formation.

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Papers (35)：

Marco Heydecker, Akiko Shitara, Desu Chen, Duy T. Tran, Andrius Masedunskas, Muhibullah S. Tora, Seham Ebrahim, Mark A. Appaduray, Jorge Luis Galeano Niño, Abhishek Bhardwaj, et al. Coordination of force-generating actin-based modules stabilizes and remodels membranes in vivo. Journal of Cell Biology. 2024. 223. 11. e202401091
Haruna Nagase, Akiko Shitara, Yuta Ohno, Keitaro Satoh, Masanori Kashimata. Loss of Cdc42 in Exocrine Acini Decreases Saliva Secretion but Increases Tear Secretion-A Potential Model of Exocrine Gland Senescence. International Journal of Molecular Sciences. 2023. 24. 24. 17220
Marco Heydecker, Akiko Shitara, Desu Chen, Duy Tran, Andrius Masedunskas, Muhibullah Tora, Seham Ebrahim, Mark A. Appaduray, Jorge Luis Galeano Niño, Abhishek Bhardwaj, et al. Spatial and Temporal Coordination of Force-generating Actin-based Modules Drives Membrane RemodelingIn Vivo. bioRxiv. 2023
Azmeree Jahan, MST Tahmina Akter, Kiwamu Takemoto, Tai Oura, Akiko Shitara, Shingo Semba, Akihiro Nezu, Satoshi Suto, Takeharu Nagai, Akihiko Tanimura. Insertion of circularly permuted cyan fluorescent protein into the ligand-binding domain of inositol 1,4,5-trisphosphate receptor for enhanced FRET upon binding of fluorescent ligand. Cell Calcium. 2022. 108. 102668-102668
大野雄太, 長瀬春奈, 佐藤慶太郎, 設楽彰子, 中本哲自, 柏俣正典. マウス唾液腺・涙腺におけるアルギナーゼ1の外分泌能調節メカニズムの解明(The mechanism of exocrine regulated by arginase 1 in mouse salivary and lacrimal glands). Journal of Oral Biosciences Supplement. 2022. 2022. 290-290

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MISC (55)：

設楽彰子, 柏俣正典. Cdc42はin vivoでマウス唾液腺の分泌顆粒の形態を制御する. Journal of Oral Biosciences Supplement. 2019. 2019. 385-385
Akiko Shitara, Lenka Malec, Seham Ebrahim, Desu Chen, Christopher Bleck, Matthew P Hoffman, Roberto Weigert. Cdc42 negatively regulates endocytosis during apical plasma membrane maintenance and development in mouse tubular organs in vivo. bioRxiv. 2018
設楽彰子, Bleck Christopher, Hoffman Matthew, Weigert Roberto. Cdc42依存性メンブレントラフィッキングによる管腔臓器の形成・維持機構. 生命科学系学会合同年次大会. 2017. 2017年度. [4P1T19-0359)]
設楽彰子. 管状臓器の管腔維持、形成におけるCdc42の役割. Journal of Oral Biosciences Supplement. 2017. 2017. 212-212
設楽彰子, Weigert Roberto. The 30th Salivary Research Colloquium"Salivary glands:an unique and valuable experimental system" 顎下腺腺腔構造維持におけるRhoGTPase Cdc42の役割. Journal of Oral Biosciences Supplement. 2016. 2016. 150-150

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Lectures and oral presentations (40)：

唾液腺細胞のCdc42欠損がSNARE発現とエンドサイトーシスに与える影響: 細胞極性と分泌機能維持の新たな制御経路
(2024)
Cdc42 Promotes Apical Membrane Formation by Regulating the Transport of Rab11a-positive Vesicles
(第97回日本薬理学会年会 2023)
低分子量Gタンパク質Cdc42はRab11aを含む輸送小胞を介して唾液腺腺房細胞の形成を制御する
(第67回日本唾液腺学会学術集会 2023)
Cdc42 Plays Opposite Roles in Different Exocrine Tissues
(EMBO WS “Trans-Scale Biology using exotic non-model organisms” 2023)
Loss of Cdc42 in exocrine glands decreases saliva secretion, but increases lacrimal fluid secretion.
(Salivary Glands and Exocrine Biology, Gordon Research Conference 2023)

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Education (2)：

2004 - 2008 Health Sciences University of Hokkaido Graduate School of Dentistry
1997 - 2003 Health Sciences University of Hokkaido School of Dentistry Department of Dentistry

Professional career (1)：

博士(歯学) (北海道医療大学)

Work history (7)：

2024/04 - 現在 Asahi University School of Dentistry
2020/06 - 2024/03 Asahi University
2019/01 - 2020/06 Asahi University School of Dentistry
2017/04 - 2018/12 Asahi University School of Dentistry
2013/04 - 2017/03 米国国立衛生研究所/米国国立癌研究所博士研究員

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Committee career (1)：

2022/04 - 現在歯科基礎医学会代議員

Awards (3)：

2021/11 - 日本唾液腺学会学会奨励賞腺房細胞におけるCdc42の欠損は唾液分泌不全を呈する
2009/07 - 第11回外分泌腺機能国際シンポジウムポスター賞
2006/10 - 第3回ニールステンセン記念国際唾液腺シンポジウムポスター賞

Association Membership(s) (4)：

日本口腔外科学会 , 日本分子生物学会 , 日本薬理学会 , 歯科基礎医学会

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