Kimura Yasuaki

キムラヤスアキ | Kimura Yasuaki

Affiliation and department：

Research field (5)： Biochemistry , Bioorganic chemistry , Structural/physical organic chemistry , Pharmaceuticals - chemistry and drug development , Chemical biology

Research keywords (4)：核酸医薬 , RNA , ケミカルバイオロジー , 核酸化学

Research theme for competitive and other funds (7)：

2022 - 2029 Dynamic Element-Effect Design for Unconventional Molecular Functions
2022 - 2026 ジスルフィドを利用したオリゴ核酸デリバリー法の深化と技術拡張
2020 - 2022 Molecular design strategy to avoid side effects of covalent drugs
2018 - 2020 標的酵素で活性化される共有結合医薬の開発
2016 - 2019 Improvement of catalytic turnover based on transition state control of oligonucleotide template chemical reaction

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Papers (45)：

Hiroshi Abe, Yasuaki Kimura, Masakazu Honma, Kosuke Nakamoto, Keiichi Motosawa, Takayuki Atago, Kana Asano, Fumitaka Hashiya, Naoko Abe, Keiko Kobayashi, et al. Position-Specific Nucleoside Sugar Modifications in mRNA ORF: Enhancing Translational Function through Complete Chemical Synthesis of mRNA. 2024
Hiroki Yamada, Hiroto Iwai, Fumitaka Hashiya, Yasuaki Kimura, Hiroshi Abe, Junichiro Yamamoto. Concise Affinity-Based Purification of Ligated mRNA for Structure-Activity Relationship Studies of Nucleosugar Modification Patterns. ChemBioChem. 2024. e202400711
hiroshi abe, Kosuke Fukuchi, Yuko Nakashima, Naoko Abe, Seigo Kimura, Fumitaka Hashiya, Yuichi Shichino, Satomi Sugiyama, Daisuke Kawaguchi, Masahito Inagaki, et al. Internal cap-initiated translation provides efficient protein production from circular mRNA. 2024
Mami Ototake, Masahito Inagaki, Seigo Kimura, Kaoru Onda, Mizuki Tada, Daisuke Kawaguchi, Hirotaka Murase, Kosuke Fukuchi, Yinuo Gao, Kengo Kokubo, et al. Development of hydrophobic tag purifying monophosphorylated RNA for chemical synthesis of capped mRNA and enzymatic synthesis of circular mRNA. Nucleic Acids Research. 2024
Kohei Nomura, Seongjin An, Yoshiaki Kobayashi, Jiro Kondo, Ting Shi, Hirotaka Murase, Kosuke Nakamoto, Yasuaki Kimura, Naoko Abe, Kumiko Ui-Tei, et al. Synthesis of 2′-formamidonucleoside phosphoramidites for suppressing the seed-based off-target effects of siRNAs. Nucleic Acids Research. 2024

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MISC (9)：

馬場麟太郎, 野村浩平, 阿部奈保子, 安成鎮, 小林芳明, 程久美子, 橋谷文貴, 木村康明, 阿部洋, 阿部洋, et al. 新規2′修飾核酸によるsiRNAの標的特異性の向上. 中部化学関係学協会支部連合秋季大会講演予稿集. 2021. 52nd (CD-ROM)
福井竜介, 新美結士, 片倉秀雄, 鈴木哲郎, 村上努, 児玉栄一, 木村康明, 阿部洋. ウイルスタンパク質の活性をトリガーとした新規不可逆阻害剤の開発. 日本薬学会年会要旨集(CD-ROM). 2019. 139th. 2. ROMBUNNO.23K-pm11-103
村上努, 木村康明, 新美結士, 藤野真之, 片倉秀雄, 鈴木哲朗, 児玉栄一, 阿部洋. ウイルスポリメラーゼの不可逆阻害を目指した新規2′-&βセレノ核酸アナログの創製. 日本エイズ学会誌. 2018. 20. 4. 468-468
村上努, 木村康明, 新美結士, 藤野真之, 片倉秀雄, 鈴木哲朗, 児玉栄一, 阿部洋. ウイルスポリメラーゼの不可逆阻害を目指した新規2'-&βセレノ核酸アナログの創製. 日本エイズ学会誌. 2018. 20. 4. 468-468
Shishido Yuko, Tomoike Fumiaki, Kimura Yasuaki, Kuwata Keiko, Yano Takato, Fukui Kenji, Fujikawa Haruka, Sekido Yoshitaka, Murakami-Tonami Yuko, Kameda Tomoshi, et al. Development of glutathione S-transferase (GST) covalent inhibitor. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2018. 255. .

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Patents (6)：

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Education (2)：

2008 - 2013 東京大学大学院薬学系研究科分子薬学専攻
2004 - 2008 The University of Tokyo

Professional career (1)：

博士(薬学) (東京大学)

Work history (8)：

2022/06 - 現在 Nagoya University Graduate School of Science Associate Professor
2020/07 - 2022/05 Nagoya University
2020/07 - 2022/05 Nagoya University Graduate School of Science
2017/06 - 2020/06 Nagoya University Nagoya University
2015/07 - 2020/06 名古屋大学大学院理学研究科助教

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Awards (2)：

2018/11 - 日本核酸化学会大塚賞
2011/10 - 公益財団法人MSD生命科学財団大津会議アワードフェロー

Association Membership(s) (5)：

JAPANESE SOCIETY FOR CHEMICAL BIOLOGY , The Japan Society of Nucleic Acids Chemistry , THE PHARMACEUTICAL SOCIETY OF JAPAN , THE CHEMICAL SOCIETY OF JAPAN , NUCLEIC ACIDS THERAPEUTICS SOCIETY OF JAPAN

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